Sano Yuto, Seki Kanae, Miyoshi Kenjirou, Sakai Toshikazu, Kadosawa Tsuyoshi, Matsuda Kazuya
Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan.
Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan.
J Vet Med Sci. 2021 Jun 2;83(5):876-880. doi: 10.1292/jvms.20-0518. Epub 2021 Apr 5.
Mediastinal masses in dogs were diagnosed as basaloid carcinoma associated with multiple thymic cysts (MTCs). The masses were composed of MTCs and proliferating intracystic neoplastic basaloid cells, which immunohistochemically diffusely expressed p63 and cytokeratin 19. A gradual transition from the basal cell layers lining the cysts walls to the neoplastic cells was seen, and it was indicated that the neoplastic cells had originated from the basal cell layers of the cysts. To the best of our knowledge, this is the first report of basaloid carcinoma occurring in the mediastinal cavity in dogs. Although these tumors were demonstrated to be rare origins, basaloid carcinoma should be included in the differential diagnoses for canine mediastinal tumors.
犬的纵隔肿块被诊断为与多发性胸腺囊肿（MTCs）相关的基底样癌。肿块由MTCs和增殖的囊内肿瘤性基底样细胞组成，这些细胞免疫组化弥漫性表达p63和细胞角蛋白19。可见从囊肿壁内衬的基底细胞层到肿瘤细胞的逐渐过渡，提示肿瘤细胞起源于囊肿的基底细胞层。据我们所知，这是犬纵隔腔发生基底样癌的首例报道。尽管这些肿瘤被证明起源罕见，但基底样癌应纳入犬纵隔肿瘤的鉴别诊断。
