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幼犬发育异常肾脏中神经元型一氧化氮合酶和肾素的表达

Expression of neuronal nitric oxide synthase and renin in dysplastic kidneys of young dogs.

作者信息

Yabuki Akira, Furusawa Yu, Miyoshi Noriaki, Taniguchi Kazuyuki, Yamato Osamu

机构信息

Laboratory of Veterinary Clinical Pathology, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima 890-0065, Japan.

Kagoshima University Veterinary Teaching Hospital, Joint Faculty of Veterinary Medicine, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan.

出版信息

J Vet Med Sci. 2021 May 17;83(5):837-840. doi: 10.1292/jvms.21-0074. Epub 2021 Apr 5.

DOI:10.1292/jvms.21-0074
PMID:33814522
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8182329/
Abstract

Renin and neuronal nitric oxide synthase in the kidney control the renin-angiotensin and tubuloglomerular feedback systems. The present study investigated the expression of renin and neuronal nitric oxide synthase in the dysplastic kidneys of three young dogs. Renin-immunoreactivity, which occurs in the juxtaglomerular and tubular cells of dysplastic kidneys, did not differ from that in the normal kidneys of young dogs. Macula densa cells in the normal kidneys showed neuronal nitric oxide synthase -immunoreactivity, but those in the dysplastic kidneys showed no apparent signals. This observation may be correlated with the pathological mechanisms of renal failure in young dogs.

摘要

肾脏中的肾素和神经元型一氧化氮合酶控制肾素-血管紧张素系统和肾小管-肾小球反馈系统。本研究调查了三只幼犬发育异常肾脏中肾素和神经元型一氧化氮合酶的表达情况。发育异常肾脏的球旁细胞和肾小管细胞中出现的肾素免疫反应性与幼犬正常肾脏中的情况并无差异。正常肾脏中的致密斑细胞显示出神经元型一氧化氮合酶免疫反应性，但发育异常肾脏中的致密斑细胞未显示出明显信号。这一观察结果可能与幼犬肾衰竭的病理机制相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96c9/8182329/c8b63a842be4/jvms-83-837-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96c9/8182329/e9b51d752fef/jvms-83-837-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96c9/8182329/c339ad8d1eb6/jvms-83-837-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96c9/8182329/5f1bd4a9fb90/jvms-83-837-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96c9/8182329/c8b63a842be4/jvms-83-837-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96c9/8182329/e9b51d752fef/jvms-83-837-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96c9/8182329/c339ad8d1eb6/jvms-83-837-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96c9/8182329/5f1bd4a9fb90/jvms-83-837-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/96c9/8182329/c8b63a842be4/jvms-83-837-g004.jpg

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本文引用的文献

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Low expression of cyclooxygenase-2 in chronic kidney disease in young dogs.年轻犬慢性肾病中环氧化酶-2的低表达
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Physiological regulation of prostaglandins in the kidney.肾脏中前列腺素的生理调节
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COX-2 activity determines the level of renin expression but is dispensable for acute upregulation of renin expression in rat kidneys.环氧化酶-2（COX-2）的活性决定肾素表达水平，但对于大鼠肾脏中肾素表达的急性上调并非必需。
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Low plasma renin and reduced renin secretory responses to acute stimuli in conscious COX-2-deficient mice.清醒的COX-2基因缺陷小鼠血浆肾素水平较低，且对急性刺激的肾素分泌反应减弱。
Am J Physiol Renal Physiol. 2007 Jan;292(1):F415-22. doi: 10.1152/ajprenal.00317.2006. Epub 2006 Sep 5.
8
Neuronal nitric oxide synthase and cyclooxygenase-2 in diabetic nephropathy of type 2 diabetic OLETF rats.2型糖尿病OLETF大鼠糖尿病肾病中神经元型一氧化氮合酶和环氧化酶-2
Exp Anim. 2006 Jan;55(1):17-25. doi: 10.1538/expanim.55.17.
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Temporal adaptation of tubuloglomerular feedback: effects of COX-2.球管反馈的时间适应性：COX-2的作用
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