Yabuki Akira, Miyazaki Akiko, Ichii Osamu, Kohyama Moeko, Sawa Mariko, Yamato Osamu
Laboratory of Veterinary Clinical Pathology, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima 890-0065, Japan.
Laboratory of Veterinary Clinical Pathology, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima 890-0065, Japan.
Res Vet Sci. 2016 Dec;109:71-73. doi: 10.1016/j.rvsc.2016.09.006. Epub 2016 Sep 13.
Chronic kidney disease (CKD) often results in end-stage renal failure in young dogs; however, the pathogenesis of this disease is not established. This study investigated renal expression of cyclooxygenase (COX)-1 and COX-2 proteins in three dogs with chronic kidney disease by immunohistochemistry. Histopathology showed asynchronous differentiation of renal tissues, including immature glomeruli. COX-1 signals were not detected in diseased or normal kidneys. COX-2 signals were low or undetectable in diseased kidneys, while normal kidneys showed clear positive signals in the macula densa (MD). Quantitative scores of COX-2 in diseased kidneys were significantly lower than those in normal kidneys. These findings demonstrate low renal COX-2 expression in CKD in young dogs, but whether this is correlated with disease pathogenesis remains unclear.
慢性肾病（CKD）常导致幼犬终末期肾衰竭；然而，该疾病的发病机制尚未明确。本研究通过免疫组织化学法调查了三只患有慢性肾病的犬肾组织中环氧化酶（COX）-1和COX-2蛋白的表达情况。组织病理学显示肾组织存在不同步分化，包括未成熟的肾小球。在患病或正常肾脏中均未检测到COX-1信号。患病肾脏中COX-2信号较低或无法检测到，而正常肾脏在致密斑（MD）处显示出清晰的阳性信号。患病肾脏中COX-2的定量评分显著低于正常肾脏。这些发现表明幼犬CKD中肾COX-2表达较低，但这是否与疾病发病机制相关仍不清楚。
