Gao Yusi, Fan Fangfang, Jia Jia, Jiang Yimeng, He Danmei, Wu Zhongli, Huo Yong, Zhou Jing, Zhang Yan
Department of Cardiology, Peking University First Hospital, Beijing, People's Republic of China.
Ther Clin Risk Manag. 2021 Mar 26;17:267-274. doi: 10.2147/TCRM.S304491. eCollection 2021.
Elevated heart rate is linked with poor prognosis and has been shown to accelerate the progress of atherosclerosis. However, the association between heart rate and new-onset PAD is unknown.
A total of 3463 participants without PAD at baseline from a community-based cohort in Beijing were included and followed up for 2.3 years. PAD was defined as ankle-brachial index (ABI) ≤0.9. We used multivariate logistic regression models to investigate the association of heart rate and the risk of new-onset PAD.
Participants were 56.67 ± 8.54 years old, and 36.12% were men. The baseline ABI was 1.11 ± 0.08, and the incidence of new-onset PAD was 2.97%. Multivariate regression models, adjusted for sex, age, risk factor of atherosclerosis, medications, and baseline ABI, showed that heart rate was significantly associated with incidence of PAD (odds ratio [OR] = 1.22, 95% confidence interval [CI]: 1.03-1.43, = 0.020); every increase of 10 heart beats per minute (bpm) was associated with a 22% increase in the odds of developing new-onset PAD. Respondents in the higher-heart rate group (≥80 bpm) had an increased risk of new-onset PAD, compared with those in the lower-heart rate group (<80 bpm) (OR = 1.73, 95% CI: 1.14-2.63, = 0.010). Subgroup analyses revealed no significant heterogeneity among the analyzed subgroups.
Elevated heart rate was independently associated with the risk of new-onset PAD in a community-based population in Beijing. Heart rate management should be considered for the purpose of PAD prevention.
心率升高与预后不良相关，且已被证明会加速动脉粥样硬化的进展。然而，心率与新发外周动脉疾病（PAD）之间的关联尚不清楚。
纳入了来自北京一个社区队列的3463名基线时无PAD的参与者，并随访2.3年。PAD定义为踝臂指数（ABI）≤0.9。我们使用多因素逻辑回归模型来研究心率与新发PAD风险之间的关联。
参与者年龄为56.67±8.54岁，36.12%为男性。基线ABI为1.11±0.08，新发PAD的发生率为2.97%。在对性别、年龄、动脉粥样硬化危险因素、药物治疗和基线ABI进行调整的多因素回归模型中，显示心率与PAD的发生率显著相关（比值比[OR]=1.22，95%置信区间[CI]：1.03 - 1.43，P = 0.020）；每分钟心率每增加10次（bpm），新发PAD的几率增加22%。与低心率组（<80 bpm）相比，高心率组（≥80 bpm）的参与者新发PAD的风险增加（OR = 1.73，95% CI：1.14 - 2.63，P = 0.010）。亚组分析显示各分析亚组之间无显著异质性。
在北京的一个社区人群中，心率升高与新发PAD的风险独立相关。为预防PAD，应考虑进行心率管理。
