Serov V V, Zolotarevskiĭ V B, Sklianskaia O A, Berestova A V
Vopr Onkol. 1988;34(5):557-62.
Mild to severe dysplasia ranked first among precancerous lesions in gastric adenoma and stomach stump gastritis. Repeated gastric biopsy of adenomas revealed enhancement of dysplasia proceeding to papillary adenocarcinoma. Epithelial dysplasia invariably occurred in areas adjacent to early carcinoma. A relationship was established between the pattern of dysplasia and histologic type of cancer. As dysplasia advanced, the ultrastructural signs of cell atypia became more pronounced. The electron microscopic features of severe dysplasia were similar to those of carcinoma.
轻至重度发育异常在胃腺瘤和残胃炎的癌前病变中位居首位。对腺瘤进行反复胃活检显示发育异常进展为乳头状腺癌。上皮发育异常总是发生在早期癌的邻近区域。发育异常的模式与癌症的组织学类型之间建立了关联。随着发育异常的进展，细胞异型性的超微结构特征变得更加明显。重度发育异常的电子显微镜特征与癌相似。
