Sechtem U, Sünger B, Kux R, Theissen P, Curtius J M, Höpp H W, Schicha H
Medizinische Klinik III, Universität zu Köln.
Z Kardiol. 1988 Mar;77(3):145-51.
Dynamic magnetic resonance imaging (MRI) was performed in patients with aortic regurgitation (N = 14) and/or mitral regurgitation (N = 13), documented and graded for severity by angiography. Eight healthy persons were studied for comparison. Turbulent retrograde blood flow through incompetent valves causes signal loss of blood, thus permitting detection of the valvular defect. To determine the severity of regurgitation by dynamic MRI, several parameters were analyzed, including the number of slices with visible signal loss, the time course of the signal loss, and its maximal area and maximal volume. All regurgitant lesions were visualized in dynamic images. The area of signal loss correlated well with the angiographic severity of aortic and mitral regurgitation. A slightly better correlation was found for the volume of signal loss. Significant differences were also found for the other parameters. Analysis of the regurgitant jet, characterized by signal loss on dynamic MR images permits a semiquantitative assessment of the severity of regurgitant lesions of left-sided valves. Three-dimensional determination of the jet volume is a possible advantage of MRI compared to other noninvasive methods.
对患有主动脉瓣反流（N = 14）和/或二尖瓣反流（N = 13）的患者进行了动态磁共振成像（MRI）检查，通过血管造影记录反流情况并对严重程度进行分级。选取8名健康人作为对照进行研究。通过功能不全瓣膜的湍流逆行血流会导致血液信号丢失，从而能够检测到瓣膜缺损。为了通过动态MRI确定反流的严重程度，分析了几个参数，包括可见信号丢失的切片数量、信号丢失的时间过程及其最大面积和最大体积。所有反流病变在动态图像中均清晰可见。信号丢失区域与主动脉瓣和二尖瓣反流的血管造影严重程度密切相关。信号丢失体积的相关性略好一些。在其他参数方面也发现了显著差异。对以动态MR图像上信号丢失为特征的反流束进行分析，可对左侧瓣膜反流病变的严重程度进行半定量评估。与其他非侵入性方法相比，MRI三维测定反流束体积是一个可能的优势。
