Stiru Ovidiu, Dragan Anca, Adamache Cristina, Dragulescu Petru Razvan, Stiru Carmen, Tulin Adrian, Bacalbasa Nicolae, Balescu Irina, Diaconu Camelia, Geana Roxana Carmen, Savu Cornel, Iliescu Vlad Anton
Department of Cardiovascular Surgery, 'Prof. Dr. C. C. Iliescu' Institute of Emergency for Cardiovascular Diseases, 022322 Bucharest, Romania.
Department of Cardiovascular Surgery, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Exp Ther Med. 2021 May;21(5):543. doi: 10.3892/etm.2021.9975. Epub 2021 Mar 23.
Paragangliomas are extremely rare neuroendocrine tumors. We report a case of a 44-year-old man with hypertension who presented a tumoral mass located retroperitoneally at the aortic bifurcation which included both the common iliac arteries and the posterior left iliac vein, who experienced an unpredictable intraoperative cardiac arrest with electromechanical dissociation at 5 min after laparotomy. After successful resuscitation and hemodynamic stability, the lesion was fully excised. In the course of tumor manipulation, the patient developed a major hypertensive crisis with peak systolic blood pressure over 280 mmHg. Pathologic examination revealed the presence of diffuse proliferation of large and medium-sized mature adipocytes consistent with paraganglioma diagnosis. The patient was discharged at home on the seventh postoperative day. He did not present evidence of recurrence at the one-year follow-up. In conclusion, paragangliomas can require particular management due to their location but also due to their capacity to discharge substances which might induce life-threatening intraoperative complications.
副神经节瘤是极其罕见的神经内分泌肿瘤。我们报告一例44岁患有高血压的男性病例,其腹膜后主动脉分叉处出现一个肿瘤性肿块,累及双侧髂总动脉和左髂后静脉,该患者在剖腹术后5分钟出现不可预测的心脏骤停伴电机械分离。成功复苏并实现血流动力学稳定后,病变被完全切除。在肿瘤操作过程中,患者出现严重高血压危象,收缩压峰值超过280 mmHg。病理检查显示存在大量和中等大小成熟脂肪细胞的弥漫性增殖,符合副神经节瘤诊断。患者术后第七天出院。在一年的随访中未发现复发迹象。总之,副神经节瘤因其位置特殊,且具有释放可能导致危及生命的术中并发症的物质的能力,可能需要特殊处理。