Chou Yu-Hsiang, Chen Yung-Ming
1Department of Internal Medicine, National Taiwan University Hospital Jin-Shan Branch, New Taipei City 20844, Taiwan.
2Renal Division, Department of Internal Medicine, and.
Aging Dis. 2021 Apr 1;12(2):515-528. doi: 10.14336/AD.2020.0703. eCollection 2021 Apr.
Chronic kidney disease (CKD) is a growing problem among aging population, and the number of individuals at risk of end stage renal disease is rising. Part of the reason lies in incomplete understanding of the pathways underlying renal aging and kidney disease, as well as insufficient delivery of evidence-based treatment to elderly patients with CKD. This review aims to address these unsolved issues by delineating updated mechanisms of renal senescence and summarizing recent findings on key clinical aspects of CKD in the elderly. Challenges and obstacles in caring for older people with CKD are discussed, with an emphasis on modification of risk factors, prevention of acute kidney injury, stabilization of progression and decision on dialysis initiation.
慢性肾脏病（CKD）在老龄化人群中是一个日益严重的问题，处于终末期肾病风险的个体数量正在增加。部分原因在于对肾脏衰老和肾病潜在机制的理解不完整，以及对老年CKD患者基于证据的治疗提供不足。本综述旨在通过阐述肾脏衰老的最新机制和总结老年人CKD关键临床方面的最新研究结果来解决这些未解决的问题。讨论了照顾老年CKD患者的挑战和障碍，重点是危险因素的修正、急性肾损伤的预防、疾病进展的稳定以及透析起始的决策。
