Schönfeld W, Knöller J, Bremm K D, Meier H, König W
Lehrstuhl für Medizinische Mikrobiologie und Immunologie, AG Infektabwehrmechanismen, Ruhr Universität, Bochum.
Zentralbl Bakteriol Mikrobiol Hyg A. 1988 Mar;267(4):537-40. doi: 10.1016/s0176-6724(88)80037-3.
The concentration of azlocillin was determined using high performance liquid chromatography in serum and chondral tissue after intravenous infusion of azlocillin (75 mg/kg body weight). In serum the levels of ten patients (2 to 27 years of age, body weight 12 to 69 kg) decreased from 478 (30 min post infusion) to 120 micrograms/ml (120 min). In contrast, the concentrations in chondral tissue ranged between 24 and 35 mg/g tissue at the corresponding times. Although the mean levels suggest a remarkable penetration of azlocillin into chondral tissue, the high individual differences observed in the tissue levels (2.1 to 138 micrograms/g tissue) require a higher dosage to ensure sufficient antimicrobial therapy in all patients.
静脉输注阿洛西林（75mg/kg体重）后，采用高效液相色谱法测定血清和软骨组织中阿洛西林的浓度。在血清中，10名患者（年龄2至27岁，体重12至69kg）的血药浓度从输注后30分钟时的478μg/ml降至120分钟时的120μg/ml。相比之下，在相应时间软骨组织中的浓度范围为24至35mg/g组织。尽管平均浓度表明阿洛西林可显著渗透至软骨组织，但在组织浓度中观察到的高个体差异（2.1至138μg/g组织）需要更高的剂量以确保对所有患者进行充分的抗菌治疗。
