Mertens J, Wustrow J, Ullmann U
Klinik und Poliklinik für Hals-Nasen-Ohrenkrankheiten, Universität Kiel.
HNO. 1988 Oct;36(10):423-5.
Azlocillin has a broad spectrum particularly against pseudomonas and should therefore be useful for preoperative parenteral treatment of infected cholesteatomas in those cases which cannot be controlled by local therapy. To determine the efficacy in treatment of cholesteatoma the concentration of azlocillin in separate tissue fractions of cholesteatoma matrix, cholesteatoma debris and granulation tissue surrounding cholesteatoma was determined. In 9 cases 2 g azlocillin was injected and in 5 cases 4 g. The concentration drop between the different tissue fractions was equal in all cases. However, as clinical experience has shown, differing high levels of azlocillin were found in comparable tissue fractions of the 14 cholesteatomas. In some of the cases the minimal antibacterial activity was not attained in the cholesteatoma fractions.
阿洛西林具有广谱抗菌活性，尤其对铜绿假单胞菌有效，因此对于那些无法通过局部治疗控制的感染性胆脂瘤患者，术前进行胃肠外给药治疗应该是有效的。为了确定阿洛西林对胆脂瘤的治疗效果，我们测定了胆脂瘤基质、胆脂瘤碎屑以及胆脂瘤周围肉芽组织中阿洛西林的浓度。9例患者注射了2g阿洛西林，5例患者注射了4g。所有病例中不同组织部分之间的浓度下降情况相同。然而，临床经验表明，在14例胆脂瘤的类似组织部分中发现了不同水平的阿洛西林。在某些病例中，胆脂瘤部分未达到最小抗菌活性。
