Thota Vihitha, Paravathaneni Mahati, Bedi Verushka, Branham Michael, Thirumaran Rajesh
Internal Medicine, Mercy Catholic Medical Center, Darby, USA.
Internal Medicine, Drexel University College of Medicine, Philadelphia, USA.
Cureus. 2021 Mar 1;13(3):e13630. doi: 10.7759/cureus.13630.
Gastric cancer is one of the most common malignancies, often detected at later stages as patients remain asymptomatic until later stages. Pernicious anemia (PA), a well-known cause of vitamin B12 deficiency, is a classic risk factor for gastric cancer. Patients with PA usually present with megaloblastic anemia and peripheral neuropathy; however, they can also present with nonspecific symptoms. We describe below the case of a 56-year-old male who presented with symptoms of nausea, vomiting, and fatigue. Initial lab work revealed severe B12 deficiency, pancytopenia, and intramedullary hemolysis warranting endoscopy that revealed a gastric fundus mass significant for adenocarcinoma on biopsy.
胃癌是最常见的恶性肿瘤之一，通常在晚期才被发现，因为患者直到晚期仍无症状。恶性贫血（PA）是维生素B12缺乏的一个众所周知的原因，是胃癌的一个典型危险因素。PA患者通常表现为巨幼细胞贫血和周围神经病变；然而，他们也可能表现出非特异性症状。我们在下面描述了一名56岁男性的病例，他出现了恶心、呕吐和疲劳症状。初步实验室检查显示严重的B12缺乏、全血细胞减少和骨髓内溶血，因此需要进行内窥镜检查，活检显示胃底肿物为腺癌。
