Ravikumar Dhanalakshmi, Ramani Pratibha, Gayathri R
Saveetha Dental College, Saveetha University, Chennai, India.
Department of Oral and Maxillofacial Pathology, Saveetha Dental College, Saveetha University, Chennai, India.
J Oral Biol Craniofac Res. 2021 Apr-Jun;11(2):308-312. doi: 10.1016/j.jobcr.2021.03.002. Epub 2021 Mar 14.
Genotypic diversity and polymorphism of Streptococcus mutans remain as a topic of interest, as this provides a satisfactory explanation for the contrasting caries status in people harboring Sterptococcus mutans. This systematic review aimed to analyze and appraise Genomic diversity of Streptococcus mutans and its relationship in Early Childhood Caries.
A literature search was conducted until August 2020 using PubMed, Cochrane central, SIGLE using search keywords and MeSH headings include "Early Childhood caries", "Streptococcus mutans" and "Genotypic diversity". Apart from the aforementioned electric search, manual search was also done. The retrieved papers were assessed by three review authors and the disagreements were discussed and the final decision was made by consensus. Qualities of the included studies were assessed and data were extracted for analysis.
A total of 4081 papers were retrieved for screening after the removal of duplicate articles. Among the retrieved studies, 4074 papers did not satisfy the study inclusion criteria. Finally, those 7 papers which fulfilled all the inclusion criteria were selected and reviewed systematically.
Genetic polymorphism and genetic mutation exist in S.mutans strain and the missense mutation varies between children with and without Early Childhood caries. The number of genotypes of S.mutans varies between caries active and caries-free children. Due to the lack of adequate studies on gene mutations for direct comparison, further studies are needed to evaluate these gene mutation and its diversities to draw a definitive conclusion.
变形链球菌的基因型多样性和多态性仍是一个备受关注的话题，因为这为携带变形链球菌的人群中龋齿状况的差异提供了令人满意的解释。本系统评价旨在分析和评估变形链球菌的基因组多样性及其与幼儿龋齿的关系。
截至2020年8月，使用PubMed、Cochrane中心、SIGLE进行文献检索，检索关键词和医学主题词包括“幼儿龋齿”、“变形链球菌”和“基因型多样性”。除了上述电子检索外，还进行了手工检索。检索到的论文由三位综述作者进行评估，讨论分歧并通过共识做出最终决定。评估纳入研究的质量并提取数据进行分析。
去除重复文章后，共检索到4081篇论文进行筛选。在检索到的研究中，4074篇论文不符合研究纳入标准。最后，选择了7篇符合所有纳入标准的论文并进行系统综述。
变形链球菌菌株存在基因多态性和基因突变，错义突变在患幼儿龋齿和未患幼儿龋齿的儿童之间有所不同。变形链球菌的基因型数量在患龋活跃儿童和无龋儿童之间有所不同。由于缺乏足够的基因突变研究进行直接比较，需要进一步研究来评估这些基因突变及其多样性，以得出明确结论。
