Thornton S N, Delaney C E, Chapman C
A.F.R.C., Institute of Animal Physiology and Genetics Research, Babraham, Cambridge, England.
Acta Endocrinol (Copenh). 1988 Feb;117(2):260-4. doi: 10.1530/acta.0.1170260.
Oxytocin, vasopressin, cortisol and testosterone levels in the plasma were measured by radioimmunoassay in intact male goats as well as in prepubertally castrated goats injected daily, for 2 weeks, with oil vehicle and then, for 4 weeks, with testosterone propionate in oil to study the influence of gonadal steroids on posterior pituitary hormones. Packed cell volume, plasma osmolality and sodium concentration were also measured in all blood samples. Plasma levels of oxytocin, vasopressin and cortisol were similar in the intact and oil-injected castrated goats. Testosterone treatment significantly increased plasma levels of oxytocin (P less than 0.01) in castrated goats but the increased levels were similar to those seen in the intact goats at the same time of year. Plasma levels of cortisol and vasopressin were unaffected by testosterone propionate treatment, whereas packed cell volume was significantly decreased (P less than 0.01). Testosterone treatment of castrated male goats appears not to have any action on pituitary hormones and oxytocin increases in the spring in both intact and castrated male goats.
通过放射免疫分析法测定了完整雄性山羊以及青春期前阉割山羊血浆中的催产素、血管加压素、皮质醇和睾酮水平。对青春期前阉割山羊每天注射油剂载体，持续2周，然后在接下来的4周内注射丙酸睾酮油剂，以研究性腺类固醇对垂体后叶激素的影响。同时还测定了所有血样的血细胞压积、血浆渗透压和钠浓度。完整山羊和注射油剂的阉割山羊血浆中的催产素、血管加压素和皮质醇水平相似。睾酮处理显著提高了阉割山羊血浆中催产素的水平（P<0.01），但升高后的水平与同年同期完整山羊的水平相似。丙酸睾酮处理对血浆皮质醇和血管加压素水平无影响，而血细胞压积则显著降低（P<0.01）。对阉割雄性山羊进行睾酮处理似乎对垂体激素没有任何作用，并且完整和阉割雄性山羊的催产素在春季都会增加。
