Thornton S N, Leng G, Bicknell R J, Chapman C, Purdew T
J Endocrinol. 1986 Aug;110(2):335-40. doi: 10.1677/joe.0.1100335.
Plasma samples obtained at 4-h intervals from goats for at least 24 h before and then during 24 h of deprivation of water were analysed by radioimmunoassay for vasopressin and oxytocin concentrations. The samples were also analysed for osmolality and sodium concentration. The differential effect of night/day versus day/night deprivation was also studied. During the two periods before the two deprivations osmolality varied in a regular manner, with low values occurring at 08.00 h. Sodium concentration followed osmolality, whereas vasopressin did not vary during the period before deprivation. During deprivation vasopressin increased along with osmolality and sodium concentration, with the beginning of the increase occurring after the morning feed. Oxytocin levels did not increase during the period of deprivation. These results do not support the hypothesis of general release of neurohypophysial hormones in response to osmotic stimuli but instead indicate there are species variations with respect to hormonal response to water deprivation.
在禁水24小时之前至少24小时以及禁水期间，每隔4小时从山羊身上采集血浆样本，通过放射免疫分析法分析血管加压素和催产素的浓度。还对样本进行了渗透压和钠浓度分析。同时研究了夜间/白天禁水与白天/夜间禁水的不同影响。在两次禁水前的两个时间段内，渗透压呈规律变化，在08:00时出现低值。钠浓度随渗透压变化，而在禁水前血管加压素没有变化。禁水期间，血管加压素随着渗透压和钠浓度的升高而增加，增加开始于早晨喂食之后。禁水期间催产素水平没有升高。这些结果不支持神经垂体激素因渗透压刺激而普遍释放的假说，而是表明在对禁水的激素反应方面存在物种差异。
