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角叉菜胶诱导的幼犬结肠炎

Carrageenan-induced coxitis in puppies.

作者信息

Bünger C, Sølund K, Joyce F, Jensen O M

机构信息

Orthopedic Hospital, Aarhus, Denmark.

出版信息

Acta Orthop Scand. 1988 Jun;59(3):249-53. doi: 10.3109/17453678809149355.

DOI:10.3109/17453678809149355
PMID:3381652
Abstract

We studied the influence of chronic synovitis and joint effusion on the blood supply and growth of the immature femoral head in 12 puppies. Twelve weekly intraarticular injections of Carrageenan solution caused unilateral coxitis with caput magnum formation. Joint pressures in the neutral position were 0.9 kPa in the coxitis hips and -0.5 kPa in the contralateral hips. The joint capsule in coxitis showed hyperemia as measured by tracer microsphere technique. In nonmedicated, awake, standing dogs there was hyperemia of both the femoral head epiphysis and the joint capsule. In all the dogs, acetabular and proximal femoral metaphyseal blood flow was unchanged. In the control group, repeated cannulation and injection of normosaline did not change the hemodynamics, joint pressure, or femoral head size. We found no evidence of femoral head ischemia in coxitis with moderate chronic elevation of resting joint pressure.

摘要

我们研究了慢性滑膜炎和关节积液对12只幼犬未成熟股骨头血液供应和生长的影响。每周关节内注射12次角叉菜胶溶液导致单侧髋关节炎并形成大头畸形。患髋中立位时的关节压力为0.9 kPa,对侧髋为-0.5 kPa。通过示踪微球技术测量,患髋的关节囊显示充血。在未用药、清醒、站立的犬中,股骨头骨骺和关节囊均有充血。所有犬的髋臼和股骨近端干骺端血流均未改变。在对照组中,重复插管和注射生理盐水并未改变血流动力学、关节压力或股骨头大小。我们没有发现静息关节压力中度慢性升高的髋关节炎中有股骨头缺血的证据。

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