Hu Qin, Zhang Shu, Zhu Jun, Yin Lina, Liu Suping, Huang Xiaowei, Ke Guihao
Department of Gynecology, Fudan University Shanghai Cancer Center, Shanghai, China.
Biomed Res Int. 2021 Mar 18;2021:6631533. doi: 10.1155/2021/6631533. eCollection 2021.
Endometrial cancer (EC) is a common gynecological malignancy worldwide whose therapy mainly depends on chemotherapy. In past years, an increasing number of studies indicate that hollow MnO could serve as a nanoplatform in the drug delivery system. The Brucea javanica oil emulsion (BJOE) has been illustrated to play a vital role in cancers. However, knowledge about the combined effect of H-MnO-PEG/BJOE in endometrial cancer remains ambiguous up to now. In the present work, we prepared a drug-delivery vector H-MnO-PEG by chemical synthesis and found that H-MnO-PEG significantly inhibited cell proliferation in endometrial cancer cells. Moreover, the combination of H-MnO-PEG/BJOE could repress cell proliferation more efficiently and promote cell apoptosis. Mechanistically, we found that BJOE exerted its role as a promoter of endometrial apoptosis by regulating relative protein expressions. In general, the present study demonstrates that H-MnO-PEG functions as a critical vector in the tumor microenvironment of endometrial cancer and the significant effect of H-MnO-PEG/BJOE on cancer cells, suggesting a new paradigm for the treatment of endometrial cancer.
子宫内膜癌（EC）是全球常见的妇科恶性肿瘤，其治疗主要依赖化疗。在过去几年中，越来越多的研究表明，中空MnO可作为药物递送系统中的纳米平台。鸦胆子油乳剂（BJOE）已被证明在癌症治疗中发挥重要作用。然而，迄今为止，关于H-MnO-PEG/BJOE在子宫内膜癌中的联合作用的认识仍不明确。在本研究中，我们通过化学合成制备了一种药物递送载体H-MnO-PEG，发现H-MnO-PEG能显著抑制子宫内膜癌细胞的增殖。此外，H-MnO-PEG/BJOE联合使用能更有效地抑制细胞增殖并促进细胞凋亡。从机制上讲，我们发现BJOE通过调节相关蛋白表达发挥其作为子宫内膜细胞凋亡促进剂的作用。总体而言，本研究表明H-MnO-PEG在子宫内膜癌的肿瘤微环境中起关键载体作用，以及H-MnO-PEG/BJOE对癌细胞具有显著作用，为子宫内膜癌的治疗提供了新的范例。
