Department of rehabilitation medicine, Shanghai University of Medicine & Health Sciences Affiliated Zhoupu Hospital, Shanghai, China.
Department of rehabilitation medicine, Minhang Hospital, Fudan University, Shanghai, China.
Nanomedicine. 2021 Apr;33:102362. doi: 10.1016/j.nano.2021.102362. Epub 2021 Jan 18.
Stroke is one of the most serious problems that seriously affect people's health and brings huge economic burden to society. The development of new nanocarriers with desired degradability and targeted ability is of great significance for efficient drug delivery. In recent years, nano drug delivery system has developed rapidly and applied to treat ischemic stroke. Here, we report the synthesis and functionalization of monodisperse hollow structured MnO (H-MnO). The highly monodisperse H-MnO with uniform morphology was obtained by in situ growing MnO on solid silica nanoparticles and subsequently removing the silica core. After successive modification of poly ethylene glycol(PEG), we further verified their protective effect on ischemic stroke in our study.
脑卒中是严重影响人们健康的最严重问题之一，给社会带来了巨大的经济负担。开发具有理想降解性和靶向能力的新型纳米载体对于高效药物传递具有重要意义。近年来，纳米药物传递系统发展迅速，并应用于治疗缺血性脑卒中。在这里，我们报告了单分散中空结构 MnO（H-MnO）的合成和功能化。通过在固体硅纳米粒子上原位生长 MnO 并随后去除硅核，得到了具有均匀形态的高度单分散 H-MnO。经过聚乙二醇（PEG）的连续修饰，我们在研究中进一步验证了它们对缺血性脑卒中的保护作用。
