Wagner P D
Department of Medicine, University of California, San Diego, La Jolla 92093.
Adv Exp Med Biol. 1988;227:245-56. doi: 10.1007/978-1-4684-5481-9_22.
This paper develops an analysis of the interaction between circulatory convective and tissue diffusive O2 transport that explains how VO2 max is set by the integrated response to each and every step in the O2 transport chain from atmosphere to mitochondria. We suggest that it is not useful to search for "the" rate limiting step determining VO2max; rather, all steps contribute. Beyond these basic concepts, the theory accounts for observations of VO2max at altitude, permits experimentally testable predictions of VO2max under a variety of conditions, explains the concept of critical O2 delivery below which VO2 cannot be maintained, and suggests an analysis to separate the contributions of central convective from peripheral diffusive adaptations to stimuli such as exercise training and chronic altitude exposure.
本文对循环对流和组织扩散性氧气运输之间的相互作用进行了分析，解释了最大摄氧量是如何由从大气到线粒体的氧气运输链中每一步的综合反应所设定的。我们认为，寻找决定最大摄氧量的“限速步骤”并无益处；相反，所有步骤都有作用。除了这些基本概念外，该理论还解释了高原地区最大摄氧量的观测结果，允许在各种条件下对最大摄氧量进行实验可测的预测，解释了临界氧气输送的概念，低于此值则无法维持摄氧量，并提出了一种分析方法，以区分中枢对流适应和外周扩散适应对运动训练和长期高原暴露等刺激的贡献。
