Ikeda Kanako, Abe Masaharu, Masamoto Izumi, Ishii Chikako, Arimura Emi, Ushikai Miharu, Oketani Kaoru, Hashiguchi Teruto, Horiuchi Masahisa
Department of Hygiene and Health Promotion Medicine Graduate School of Medical and Dental Sciences, Kagoshima University Kagoshima Japan.
Department of Clinical Laboratory Kagoshima University Medical and Dental Hospital Kagoshima Japan.
Health Sci Rep. 2021 Mar 26;4(2):e267. doi: 10.1002/hsr2.267. eCollection 2021 Jun.
The early and reliable detection of chronic kidney disease is important. In the present study, we aimed to compare the diagnostic results for proteinuria and hematuria between the dipstick test used in primary occupational health examinations and the quantitative tests used in more thorough examinations in clinics.
We conducted a single-center observational study of male staff (N = 573) at Kagoshima University who underwent a health examination in 2017. Both dipsticks and biochemical methods were used to assess proteinuria and hematuria.
For the dipstick test, the sensitivity, specificity, and positive predictive value were 55.6%, 92.4% and 10.4% for proteinuria, and 64.3%, 98.3% and 66.7% for hematuria, respectively. Four participants for whom false-negative results were obtained using dipsticks for proteinuria, and two of these had 3+ urinary glucose.
Qualitative tests for proteinuria and hematuria had low sensitivities and positive predictive values. Therefore, for the early and reliable detection of chronic kidney disease, the use of quantitative urine tests should be considered during occupational health examinations.
慢性肾脏病的早期及可靠检测至关重要。在本研究中，我们旨在比较初级职业健康检查中使用的试纸法检测蛋白尿和血尿的诊断结果与临床更全面检查中使用的定量检测方法的诊断结果。
我们对2017年在鹿儿岛大学接受健康检查的男性职员（N = 573）进行了单中心观察性研究。同时使用试纸法和生化方法评估蛋白尿和血尿。
对于试纸法检测，蛋白尿的灵敏度、特异度和阳性预测值分别为55.6%、92.4%和10.4%，血尿的灵敏度、特异度和阳性预测值分别为64.3%、98.3%和66.7%。有4名参与者使用试纸法检测蛋白尿时出现假阴性结果，其中2人尿糖为3+。
蛋白尿和血尿的定性检测灵敏度和阳性预测值较低。因此，为了早期且可靠地检测慢性肾脏病，在职业健康检查中应考虑使用尿液定量检测。
