Hernández-Avalos Ismael, Valverde Alex, Antonio Ibancovichi-Camarillo José, Sánchez-Aparicio Pedro, Recillas-Morales Sergio, Rodríguez-Velázquez Desiderio, Osorio-Avalos Jorge, Armando Magdaleno-Torres Luis, Chavez-Monteagudo Julio, Manuel Acevedo-Arcique Carlos
Department of Biological Sciences, Clinical Pharmacology and Veterinary Anaesthesia, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, Cuautitlán Izcalli, Estado de México, 54740 Estado Mexico.
Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario, N1G 2W1 Canada.
J Vet Res. 2021 Jan 26;65(1):117-123. doi: 10.2478/jvetres-2021-0004. eCollection 2021 Mar.
While the current tools to assess canine postoperative pain using physiological and behavioural parameters are reliable, an objective method such as the parasympathetic tone activity (PTA) index could improve postoperative care. The aim of the study was to determine the utility of the PTA index in assessing postoperative analgaesia.
Thirty healthy bitches of different breeds were randomly allocated into three groups for analgaesic treatment: the paracetamol group (G, n = 10) received 15 mg/kg b.w., the carprofen group (G, n = 10) 4 mg/kg b.w., and the meloxicam group (G, n = 10) 0.2 mg/kg b.w. for 48 h after surgery. G was medicated orally every 8 h, while G and G were medicated intravenously every 24 h. The PTA index was used to measure the analgaesia-nociception balance 1 h before surgery (baseline), and at 1, 2, 4, 6, 8, 12, 16, 20, 24, 36, and 48 h after, at which times evaluation on the University of Melbourne Pain Scale (UMPS) was made.
The baseline PTA index was 65 ± 8 for G, 65 ± 7 for G, and 62 ± 5 for G. Postoperatively, it was 65 ± 9 for G, 63 ± 8 for G, and 65 ± 8 for G. No statistically significant difference existed between baseline values or between values directly after treatments (P = 0.99 and P = 0.97, respectively). The PTA index showed a sensitivity of 40%, specificity of 98.46% and a negative predictive value of 99.07%.
Our findings suggest that the PTA index measures comfort and postoperative analgaesia objectively, since it showed a clinical relationship with the UMPS.
虽然目前使用生理和行为参数评估犬术后疼痛的工具是可靠的，但诸如副交感神经张力活动（PTA）指数这样的客观方法可能会改善术后护理。本研究的目的是确定PTA指数在评估术后镇痛中的效用。
将30只不同品种的健康母犬随机分为三组进行镇痛治疗：扑热息痛组（G，n = 10）接受15mg/kg体重，卡洛芬组（G，n = 10）4mg/kg体重，美洛昔康组（G，n = 10）0.2mg/kg体重，术后持续48小时。G组每8小时口服给药一次，而G组和G组每24小时静脉给药一次。PTA指数用于在手术前1小时（基线）以及术后1、2、4、6、8、12、16、20、24、36和48小时测量镇痛-伤害感受平衡，在此期间对墨尔本大学疼痛量表（UMPS）进行评估。
G组的基线PTA指数为65±8，G组为65±7，G组为62±5。术后，G组为65±9，G组为63±8，G组为65±8。基线值之间或治疗后直接测量的值之间均无统计学显著差异（分别为P = 0.99和P = 0.97）。PTA指数显示敏感性为40%，特异性为98.46%，阴性预测值为99.07%。
我们的研究结果表明，PTA指数客观地测量了舒适度和术后镇痛效果，因为它与UMPS显示出临床相关性。
