Aikawa M
Bull World Health Organ. 1977;55(2-3):139-56.
The fine structure of malarial parasites is reviewed and the function of the intracellular organelles is discussed. When the erythrocytic, exoerythrocytic, and mosquito stages of plasmodia are compared, substantial differences are seen. The major differences involve the amount of surface coat of the motile forms, the structure and function of the mitochondria, and the ingestion and digestion of nutrients. Significant structural differences are also observed between comparable stages of mammalian and avian parasites. These differences indicate that malarial parasites adapt themselves to the different environments in which the parasite resides.When host cell changes induced by malarial parasite infection are reviewed, alterations characteristic of the infecting plasmodia are observed in erythrocytes. Erythrocyte changes include caveola-vesicle complexes, excrescences, and clefts. The caveola-vesicle complexes possess malarial antigens and exhibit pinocytotic activities. The excrescences form focal junctions with adjacent cells and may be responsible for infected erythrocyte sequestration in organs. The significance of these host cell changes specific to certain species of malarial parasite is still unknown.
本文综述了疟原虫的精细结构，并讨论了细胞内细胞器的功能。当比较疟原虫的红细胞内期、红细胞外期和蚊期时，可以看到显著差异。主要差异涉及活动形式的表面被膜数量、线粒体的结构和功能以及营养物质的摄取和消化。在哺乳动物和鸟类寄生虫的可比阶段之间也观察到显著的结构差异。这些差异表明疟原虫能够适应其所处的不同环境。当回顾疟原虫感染引起的宿主细胞变化时，在红细胞中观察到了感染疟原虫特有的改变。红细胞变化包括小窝-囊泡复合体、突起和裂隙。小窝-囊泡复合体含有疟原虫抗原并表现出胞饮活性。突起与相邻细胞形成紧密连接，可能是导致受感染红细胞在器官中滞留的原因。这些特定种类疟原虫引起的宿主细胞变化的意义尚不清楚。
