School of Dental Sciences, Newcastle University, Newcastle upon Tyne, UK.
School of Dentistry, University of Dundee, Dundee, UK.
J Clin Periodontol. 2021 Aug;48(8):1093-1102. doi: 10.1111/jcpe.13465. Epub 2021 May 17.
To assess the efficacy of a commercially available adjunctive phototherapy protocol ("Perio-1") in treatment of periodontitis.
In an examiner-blind, randomized, controlled, split-mouth, multicentre study, 60 periodontitis patients received root surface debridement (RSD) in sextants either alone (control sextants) or with the adjunctive phototherapy protocol (test sextants). Re-evaluation was performed at 6, 12 and 24 weeks.
No statistically significant differences in mean (± standard deviation) clinical attachment level (CAL) change from baseline to week 24 were observed between test (-1.00 ± 1.16 mm) and control sextants (-0.87 ± 0.79 mm) at sites with probing pocket depths (PPDs) ≥5 mm ("deep sites") at baseline (p = .212). Comparisons between test and control sextants for all other parameters (CAL change at all sites, PPD change at deep sites/all sites, bleeding on probing, plaque scores), and for all change intervals, failed to identify any statistically significant differences.
The phototherapy protocol did not provide any additional clinical benefits over those achieved by RSD alone. (German Clinical Trials Register DRKS00011229).
评估一种市售的辅助光疗方案（“Perio-1”）在治疗牙周炎方面的疗效。
在一项盲法、随机、对照、分侧、多中心研究中，60 名牙周炎患者接受了象限内的根面清创术（RSD），单独（对照组象限）或联合辅助光疗方案（实验组象限）。在 6、12 和 24 周进行重新评估。
在基线至 24 周时，深度探诊口袋深度（PPD）≥5 毫米的位点（“深位点”）的平均（±标准差）临床附着水平（CAL）变化，实验组（-1.00±1.16 毫米）和对照组（-0.87±0.79 毫米）之间无统计学显著差异（p=0.212）。对于所有其他参数（所有位点的 CAL 变化、深位点/所有位点的 PPD 变化、探诊出血、菌斑评分）以及所有变化间隔，实验组和对照组之间的比较均未发现任何统计学显著差异。
与单独的 RSD 相比，光疗方案并未提供任何额外的临床益处。（德国临床试验注册 DRKS00011229）。
