Najm Kashan Kamal, Gul Sarhang Sarwat, Abdulkareem Ali Abbas
Department of Periodontics, College of Dentistry, University of Sulaimani, Sulaymaniyah 46001, Iraq.
Medical Laboratory Department, College of Health and Medical Technology, Sulaimani Polytechnic University, Sulaymaniyah 46001, Iraq.
Clin Pract. 2024 May 22;14(3):954-964. doi: 10.3390/clinpract14030076.
This study aimed to examine the efficacy of methylene blue (MB) and toluidine blue O (TBO) photodynamic therapy (PDT) as adjuncts to root surface debridement (RSD).
This split-mouth, randomized, controlled clinical trial included eighteen patients, and a total of 332 sites (control = 102, MB = 124 and TBO = 106) were examined. Two sessions of PDT were completed at baseline and two weeks after RSD. Clinical parameters of bleeding on probing (BOP), plaque index (PI), probing pocket depth (PPD), and clinical attachment level (CAL) were measured pre- and post-treatment.
PPD and BOP reductions in sites treated by RSD with adjunctive photosensitizers (MB and TBO) were significantly higher than in control sites. RSD with MB showed higher efficacy in improving moderately deep pockets (OR 3.350), while adjunctive TBO showed better results in treating deeper pockets (OR 4.643).
Results suggested that adjunctive use of MB and TBO to RSD could significantly improve periodontal pocket closure and reduce signs of inflammation. In addition, TBO seems to be more efficient in treating deep periodontal pockets than MB, which is more effective in resolving shallower pockets.
本研究旨在探讨亚甲蓝（MB）和甲苯胺蓝O（TBO）光动力疗法（PDT）作为根面清创术（RSD）辅助治疗手段的疗效。
这项双盲、随机、对照临床试验纳入了18名患者，共检查了332个位点（对照组 = 102个，MB组 = 124个，TBO组 = 106个）。在基线时以及RSD后两周完成了两轮PDT治疗。在治疗前后测量了探诊出血（BOP）、菌斑指数（PI）、探诊深度（PPD）和临床附着水平（CAL）等临床参数。
使用辅助光敏剂（MB和TBO）的RSD治疗位点的PPD和BOP降低幅度显著高于对照位点。RSD联合MB在改善中度深牙周袋方面显示出更高的疗效（比值比3.350），而辅助使用TBO在治疗较深牙周袋方面效果更好（比值比4.643）。
结果表明，RSD联合使用MB和TBO可显著改善牙周袋闭合并减轻炎症迹象。此外，TBO在治疗深牙周袋方面似乎比MB更有效，而MB在解决较浅牙周袋方面更有效。
