非手术牙周治疗联合亚甲蓝和甲苯胺蓝 O 介导的光动力疗法治疗牙周炎的疗效：一项随机临床试验

Efficacy of Non-Surgical Periodontal Therapy with Adjunctive Methylene Blue and Toluidine Blue O Mediated Photodynamic in Treatment of Periodontitis: A Randomized Clinical Trial.

作者信息

Najm Kashan Kamal, Gul Sarhang Sarwat, Abdulkareem Ali Abbas

机构信息

Department of Periodontics, College of Dentistry, University of Sulaimani, Sulaymaniyah 46001, Iraq.

Medical Laboratory Department, College of Health and Medical Technology, Sulaimani Polytechnic University, Sulaymaniyah 46001, Iraq.

出版信息

Clin Pract. 2024 May 22;14(3):954-964. doi: 10.3390/clinpract14030076.

DOI:10.3390/clinpract14030076

PMID:38804408

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11130800/

Abstract

BACKGROUND

This study aimed to examine the efficacy of methylene blue (MB) and toluidine blue O (TBO) photodynamic therapy (PDT) as adjuncts to root surface debridement (RSD).

METHODS

This split-mouth, randomized, controlled clinical trial included eighteen patients, and a total of 332 sites (control = 102, MB = 124 and TBO = 106) were examined. Two sessions of PDT were completed at baseline and two weeks after RSD. Clinical parameters of bleeding on probing (BOP), plaque index (PI), probing pocket depth (PPD), and clinical attachment level (CAL) were measured pre- and post-treatment.

RESULTS

PPD and BOP reductions in sites treated by RSD with adjunctive photosensitizers (MB and TBO) were significantly higher than in control sites. RSD with MB showed higher efficacy in improving moderately deep pockets (OR 3.350), while adjunctive TBO showed better results in treating deeper pockets (OR 4.643).

CONCLUSIONS

Results suggested that adjunctive use of MB and TBO to RSD could significantly improve periodontal pocket closure and reduce signs of inflammation. In addition, TBO seems to be more efficient in treating deep periodontal pockets than MB, which is more effective in resolving shallower pockets.

摘要