Department of Geriatrics, Florida State University College of Medicine, Tallahassee, Florida, USA.
Euromov, University of Montpellier, Montpellier, France.
Mov Disord. 2021 Aug;36(8):1863-1870. doi: 10.1002/mds.28575. Epub 2021 Apr 4.
Neuroticism is linked to mood disorders and Alzheimer's disease, but fewer studies have tested the prospective association with Parkinson's disease (PD).
To examine the association between neuroticism and risk of PD in a large cohort and a meta-analysis of prospective cohort studies.
Participants from the UK Biobank (N = 490,755) completed a neuroticism scale in 2006-2010. Incident PD was ascertained using electronic health records or death records up to 2018. The systematic search and meta-analysis followed the MOOSE guidelines.
During 11.91 years of follow-up (mean = 8.88 years; 4,360,105 person-years) 1142 incident PD cases were identified. Neuroticism was associated with higher risk of incident PD, both as continuous (HR = 1.28; 95% CI: 1.21-1.36) and categorical variable (top vs. bottom quartiles: HR = 1.88; 95% CI: 1.60-2.22). The association remained significant after accounting for age, sex, smoking, physical activity, anxiety, and depressed mood, and after excluding cases that occurred within the first 5 years of follow-up. The associations were similar for women and men and across levels of socioeconomic status. Random-effect meta-analysis of four prospective studies (N = 548,284) found neuroticism associated with increased risk of incident PD (HR = 1.82; 95% CI: 1.59-2.08; P = 7.31 ). There was no evidence of heterogeneity across studies with follow-ups ranging from one to four decades.
The results from the large UK Biobank and meta-analysis of prospective studies indicate that neuroticism is consistently associated with a higher risk of incident PD. © 2021 International Parkinson and Movement Disorder Society.
神经质与心境障碍和阿尔茨海默病有关，但较少的研究测试了其与帕金森病（PD）的前瞻性关联。
在一个大型队列和前瞻性队列研究的荟萃分析中，研究神经质与 PD 风险之间的关联。
英国生物库（UK Biobank）的参与者（N=490755）于 2006-2010 年完成了神经质量表的测试。通过电子健康记录或死亡记录，直至 2018 年确定 PD 的发病情况。系统检索和荟萃分析遵循 MOOSE 指南。
在 11.91 年的随访期间（平均=8.88 年；4360105 人年），共确定了 1142 例 PD 发病病例。神经质与 PD 发病风险增加相关，无论是作为连续变量（HR=1.28；95%CI：1.21-1.36）还是分类变量（最高与最低四分位数：HR=1.88；95%CI：1.60-2.22）。在考虑了年龄、性别、吸烟、身体活动、焦虑和抑郁情绪后，并且排除了随访前 5 年内发生的病例后，这种关联仍然显著。这种关联在女性和男性以及社会经济地位的各个水平上都是相似的。对四项前瞻性研究（N=548284）的随机效应荟萃分析发现，神经质与 PD 发病风险增加相关（HR=1.82；95%CI：1.59-2.08；P=7.31）。研究的随访时间从 1 年到 40 年不等，没有异质性的证据。
来自英国生物库的大型研究和前瞻性研究的荟萃分析结果表明，神经质与 PD 发病风险增加密切相关。© 2021 国际帕金森病和运动障碍学会。
