焦虑特质与帕金森病风险的关联：一项基于457,180名英国生物银行参与者的纵向研究。

Association of worrier trait with the risk of Parkinson's disease: a longitudinal study based on 457,180 UK Biobank participants.

作者信息

Li Rui, Ling Yitong, Pan Ao, Cao Rui, Lyu Jun, Bi Wei

机构信息

Department of Neurology, The First Affiliated Hospital of Jinan University, Guangzhou, China.

Department of Clinical Research, The First Affiliated Hospital of Jinan University, Guangzhou, China.

出版信息

Front Psychol. 2025 Mar 25;16:1440199. doi: 10.3389/fpsyg.2025.1440199. eCollection 2025.

DOI:10.3389/fpsyg.2025.1440199

PMID:40231002

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11995634/

Abstract

OBJECTIVE

To explore the potential association between the trait of being a worrier and the likelihood of developing Parkinson's disease (PD).

BACKGROUND

While extensive research has explored the link between PD and disorders such as depression and anxiety, limited research has been conducted on the association between worry and PD.

METHODS

This prospective cohort study utilized data obtained from the UK Biobank, with baseline assessments conducted between 2006 and 2010 and follow-up until July 16, 2023. Multivariable Cox proportional hazards regression analysis was carried out to evaluate the link between worrier trait and the development of PD. Adjustments were made for demographic factors, smoking, PD polygenetic risk scores, alcohol consumption, body mass index, physical activity, stroke, diabetes, hypertension, heart attack, and psychiatric history. Subgroup and sensitivity analyses were additionally conducted to validate the reliability of the outcomes.

RESULTS

Over a mean follow-up period of 13.5 years, 3123 participants (0.68%) out of 457,180 participants [median (IQR) age, 58.00 (50.00, 63.00) years; 54.3% female] developed PD. The incidence of PD was positively linked to worry (log-rank test, < 0.001). Furthermore, worriers demonstrated a heightened risk of developing PD [hazard ratio (HR) 1.32, 95% CI 1.23-1.42]. Importantly, this link persisted even following adjustments for covariates (fully adjusted model HR 1.27, 95% CI 1.18-1.37). Additionally, when cases within the initial 5 years of follow-up were excluded, the significance of the association persisted (HR: 1.28, 95% CI 1.18-1.38). In subgroup analyses categorized by age, early-onset PD (age < 60 years) showed a stronger association than late-onset PD (age ≥ 60 years; early-onset PD HR 1.32, 95% CI 0.86-2.03; late-onset PD HR 1.13, 95% CI 1.05-1.22).

CONCLUSION

These findings suggest that the worrier trait is consistently associated with a higher risk of developing PD, particularly among young individuals, highlighting the importance of mental wellness.

摘要

目的

探讨担忧特质与患帕金森病（PD）可能性之间的潜在关联。

背景

虽然已有广泛研究探索了PD与抑郁症和焦虑症等疾病之间的联系，但关于担忧与PD之间关联的研究较少。

方法

这项前瞻性队列研究利用了从英国生物银行获得的数据，基线评估在2006年至2010年期间进行，随访至2023年7月16日。进行多变量Cox比例风险回归分析以评估担忧特质与PD发生之间的联系。对人口统计学因素、吸烟、PD多基因风险评分、饮酒、体重指数、身体活动、中风、糖尿病、高血压、心脏病发作和精神病史进行了调整。还进行了亚组分析和敏感性分析以验证结果的可靠性。

结果

在平均13.5年的随访期内，457,180名参与者（年龄中位数[四分位间距]为58.00[50.00,63.00]岁；54.3%为女性）中有3123名参与者（0.68%）患上了PD。PD的发病率与担忧呈正相关（对数秩检验，<0.001）。此外，担忧者患PD的风险更高[风险比（HR）为1.32，95%置信区间为1.23 - 1.42]。重要的是，即使在对协变量进行调整后，这种联系仍然存在（完全调整模型HR为1.27，95%置信区间为1.18 - 1.37）。此外，当排除随访最初5年内的病例时，该关联的显著性仍然存在（HR：1.28，95%置信区间为1.18 - 1.38）。在按年龄分类的亚组分析中，早发性PD（年龄<60岁）显示出比晚发性PD（年龄≥60岁；早发性PD HR为1.32，95%置信区间为0.86 - 2.03；晚发性PD HR为1.13，95%置信区间为1.05 - 1.22）更强的关联。