Department of Clinical Studies, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
Physiol Rep. 2021 Apr;9(7):e14822. doi: 10.14814/phy2.14822.
The present study investigated the effects of Shilajit extract on aspirin-induced gastric lesions in rats. We evaluated macroscopic and histopathological lesions in the stomach, measured the activity of oxidative stress enzymes in gastric tissue homogenates, and assessed serum electrolytes and parameters of kidney and liver function. Forty-five male rats were allocated to five groups: Normal control, positive control, omeprazole treatment, Shilajit treatment, and Shilajit control. The treatment period lasted for four consecutive days. The size and number of gastric lesions were significantly reduced in the Shilajit and omeprazole groups compared to the positive control group, indicating a reduction in mucosal damage and the severity of edema and leukocyte infiltration in tissue sections. A significant increase was observed in the levels of all oxidative stress parameters, except malondialdehyde, in rats treated with Shilajit and omeprazole compared to those in the positive control group. The effect of the aqueous extract of Shilajit was comparable to that of omeprazole. These results indicated the protective effects of Shilajit against aspirin-induced gastric lesions.
本研究探讨了喜来芝提取物对阿司匹林诱导的大鼠胃损伤的影响。我们评估了胃的宏观和组织病理学损伤，测量了胃组织匀浆中氧化应激酶的活性，并评估了血清电解质以及肾功能和肝功能的参数。将 45 只雄性大鼠分配到五个组：正常对照组、阳性对照组、奥美拉唑治疗组、喜来芝治疗组和喜来芝对照组。治疗期持续四天。与阳性对照组相比，喜来芝和奥美拉唑组的胃损伤大小和数量明显减少，这表明组织切片中的粘膜损伤以及水肿和白细胞浸润的严重程度降低。与阳性对照组相比，喜来芝和奥美拉唑治疗组的所有氧化应激参数水平（除丙二醛外）均显著升高。喜来芝水提取物的作用可与奥美拉唑相媲美。这些结果表明喜来芝对阿司匹林诱导的胃损伤具有保护作用。
