Department of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.
Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.
Med Gas Res. 2021 Apr-Jun;11(2):83-87. doi: 10.4103/2045-9912.311499.
Hydrogen sulfide (HS) is recognized to be a novel mediator after carbon monoxide and nitric oxide in the organism. It can be produced in various mammalian tissues and exert many physiological effects in many systems including the cardiovascular system. A great amount of recent studies have demonstrated that endogenous HS and exogenous HS-releasing compounds (such as NaHS, NaS, and GYY4137) provide protection in many cardiovascular diseases, such as ischemia/reperfusion injury, heart failure, cardiac hypertrophy, and atherosclerosis. In recent years, many mechanisms have been proposed and verified the protective role exhibited by HS against myocardial ischemia/reperfusion injury, and this review is to demonstrate the protective role of exogenous and endogenous HS on myocardial ischemia/reperfusion injury.
硫化氢（HS）是继一氧化碳和一氧化氮之后在体内被发现的一种新型介质。它可以在各种哺乳动物组织中产生，并在包括心血管系统在内的许多系统中发挥许多生理作用。大量最近的研究表明，内源性 HS 和外源性 HS 释放化合物（如 NaHS、NaS 和 GYY4137）在许多心血管疾病中提供保护，如缺血/再灌注损伤、心力衰竭、心肌肥厚和动脉粥样硬化。近年来，许多机制被提出并验证了 HS 对心肌缺血/再灌注损伤的保护作用，本综述旨在展示外源性和内源性 HS 对心肌缺血/再灌注损伤的保护作用。
