硫化氢开关现象调控心血管疾病自噬。

Hydrogen Sulfide Switch Phenomenon Regulating Autophagy in Cardiovascular Diseases.

机构信息

Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, University of South China, Hengyang, 421001, Hunan Province, China.

Medical Record Statistics Office and Library, The Pediatric Academy of University of South China, Changsha, 410007, Hunan Province, China.

出版信息

Cardiovasc Drugs Ther. 2020 Feb;34(1):113-121. doi: 10.1007/s10557-019-06927-4.

DOI:10.1007/s10557-019-06927-4

PMID:32090295

Abstract

Hydrogen sulfide (HS), a novel gaseous signaling molecule, is a vital physiological signal in mammals. HS protects the cardiovascular system via modulation of vasodilation, vascular remodeling, and inhibition of vascular calcification, and also has anti-atherosclerosis properties. Autophagy is a lysosomal-mediated intracellular degradation mechanism for excessive or abnormal proteins and lipids. The contribution of autophagy to normal and disease-state cell physiology is extremely complicated. Autophagy acts as a double-edged sword in the cardiovascular system. It can defend against damage to cells caused by environmental changes and it can also induce active cell death under certain conditions. In recent years, accumulating evidence indicates that HS can up- or downregulate autophagy in many pathological processes, thereby switching from a harmful to a beneficial role. In this review, we summarize progress on understanding the mechanism by which HS regulates autophagy in cardiovascular disease. We also discuss a HS switch phenomenon that regulates autophagy and provides protection in cardiovascular diseases.

摘要

硫化氢（HS）作为一种新型气体信号分子，是哺乳动物中重要的生理信号。HS 通过调节血管舒张、血管重塑和抑制血管钙化来保护心血管系统，同时具有抗动脉粥样硬化作用。自噬是溶酶体介导的细胞内过度或异常蛋白质和脂质的降解机制。自噬对正常和疾病状态下细胞生理学的贡献极其复杂。自噬在心血管系统中充当双刃剑。它可以抵御环境变化引起的细胞损伤，也可以在某些条件下诱导主动细胞死亡。近年来，越来越多的证据表明，HS 可以在许多病理过程中上调或下调自噬，从而从有害作用转变为有益作用。在这篇综述中，我们总结了理解 HS 调节心血管疾病中自噬机制的研究进展。我们还讨论了 HS 调节自噬的开关现象，该现象为心血管疾病提供了保护作用。