Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.
Department of Dermatologic Surgery, Shanghai Skin Diseases Hospital, Shanghai, China.
Photodiagnosis Photodyn Ther. 2021 Jun;34:102277. doi: 10.1016/j.pdpdt.2021.102277. Epub 2021 Apr 2.
Epidermodysplasia verruciformis (EV) is a rare autosomal recessive disorder. Individuals with EV are more susceptible to the development of cutaneous neoplasia in sun-exposed regions. This disease should be closely observed for cutaneous squamous cell carcinoma (cSCC) or pre-cancerous lesions - if neoplasia is found, it should be removed. A 68-year-old woman with EV had a post-operative recurrent, invasive cSCC growing on her upper-left eyelid. Although the standard treatment for cSCC is surgical excision, it is challenging to reach the deepest regions. Herein, we reported a case of a recurrent, invasive cSCC effectively treated by a combination of non-invasive 5-aminolevulinic acid-mediated photodynamic therapy (ALA-PDT) and deep-penetrative holmium laser. The results were satisfactory without any adverse effects to the patient.
疣状表皮发育不良（EV）是一种罕见的常染色体隐性遗传病。EV 患者在暴露于阳光的区域更容易发生皮肤肿瘤。对于皮肤鳞状细胞癌（cSCC）或癌前病变，应密切观察——如果发现肿瘤，应予以切除。一位 68 岁的 EV 女性患者，左上眼睑有术后复发的侵袭性 cSCC。尽管 cSCC 的标准治疗方法是手术切除，但要达到最深层区域仍具有挑战性。在此，我们报告了一例通过非侵入性 5-氨基酮戊酸介导的光动力疗法（ALA-PDT）和深层穿透钬激光联合治疗复发性侵袭性 cSCC 的病例。结果令人满意，患者无任何不良反应。
