Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, Jiangsu 210042, China.
Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, Jiangsu 210042, China.
Photodiagnosis Photodyn Ther. 2023 Dec;44:103844. doi: 10.1016/j.pdpdt.2023.103844. Epub 2023 Oct 12.
Cutaneous squamous cell carcinoma (cSCC) is a common malignant skin tumor. Some invasive cSCC can cause severe cosmetic damage; therefore, comprehensive measures should be taken. Here, we present a case of a 48-year-old male patient with invasive cSCC on the nose. The lesion recurred twice after excision in the other hospital. After admission, the patient underwent surgical excision; however, the tumor remained because of its deep infiltration, and we left the wound exposed without repair. During the period of open-wound, the patient received 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) to completely clear the residual tumors, and multipoint biopsies were performed to monitor the tumor remission process. We reconstructed the defect by using bilateral flaps after complete remission. The tumor did not recur in 63 months of follow-up after reconstruction. Open-wound treatment should be considered for tumors that occur at high-risk sites such as the nose. Surgery combined with PDT may be an efficient method for treating cSCC.
皮肤鳞状细胞癌（cSCC）是一种常见的恶性皮肤肿瘤。一些侵袭性 cSCC 会导致严重的美容损伤；因此，应采取综合措施。在这里，我们报告了一例 48 岁男性鼻部侵袭性 cSCC 患者。该病变在其他医院切除后复发了两次。入院后，患者接受了手术切除；然而，由于肿瘤浸润较深，肿瘤仍然存在，我们让伤口暴露而不修复。在开放性伤口期间，患者接受了基于 5-氨基酮戊酸的光动力疗法（ALA-PDT）以完全清除残留肿瘤，并进行多点活检以监测肿瘤缓解过程。完全缓解后，我们使用双侧皮瓣重建了缺损。重建后 63 个月的随访中，肿瘤未复发。对于发生在高危部位（如鼻子）的肿瘤，应考虑开放性伤口治疗。手术联合 PDT 可能是治疗 cSCC 的有效方法。
