一种用于微量测定血浆或血清中丙戊酸钠（二 - N - 丙基乙酸钠）的快速灵敏的气液色谱法。
A rapid and sensitive gas-liquid chromatographic procedure for the micro determination of sodium valproate (sodium di-N-propylacetate) in plasma or serum.
作者信息
Fellenberg A J, Pollard A C
出版信息
Clin Chim Acta. 1977 Dec 1;81(2):203-8. doi: 10.1016/0009-8981(77)90012-2.
A gas-liquid chromatographic procedure for the micro determination of sodium valproate is described. Valproic acid is extracted from acidified plasma or serum into n-heptane containing an internal standard (octanoic acid) and after phase separation an aliquot is analysed by gas-liquid chromatography. The procedure is rapid, reliable, sensitive and specific. It requires 25--50 microliter sample for a single estimation, has a detection threshold of less than 10 mumol/l, and is suitable for routine clinical use.
本文描述了一种用于微量测定丙戊酸钠的气-液色谱法。将丙戊酸从酸化的血浆或血清中萃取到含有内标（辛酸）的正庚烷中，经过相分离后，取一份样品进行气-液色谱分析。该方法快速、可靠、灵敏且特异。单次测定仅需25 - 50微升样品，检测阈值低于10微摩尔/升，适用于临床常规应用。
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