气液色谱法快速测定血清中丙戊酸钠
Rapid determination of valproate sodium in serum by gas-liquid chromatography.
作者信息
Löscher W
出版信息
Epilepsia. 1977 Jun;18(2):225-7. doi: 10.1111/j.1528-1157.1977.tb04469.x.
Abstract
A rapid and simple gas-liquid chromatographic procedure is described for the measurement of valproate sodium (sodium di-n-propylacetate) in serum. Valproate is extracted from serum by a micro-extraction method and chromatographed on a 10% Carbowax 6000 column using 2-ethyl-2-methyl-caproic acid as internal standard. The method is capable of measuring at least 2 microgram of valproate per milliliter serum.
摘要
本文描述了一种快速简便的气-液色谱法，用于测定血清中的丙戊酸钠（二正丙基乙酸钠）。丙戊酸通过微萃取法从血清中提取，并以2-乙基-2-甲基己酸为内标，在10%聚乙二醇6000柱上进行色谱分析。该方法能够测定每毫升血清中至少2微克的丙戊酸。
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