Apheresis and Dialysis Center, School of Medicine, Keio University, Tokyo, Japan.
Department of Nephrology, School of Medicine, International University of Health and Welfare, Otawara, Japan.
Ren Fail. 2021 Dec;43(1):651-657. doi: 10.1080/0886022X.2021.1910045.
Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease. Although several cases of BP in end-stage renal disease patients receiving peritoneal dialysis (PD) or hemodialysis have been reported, the incidence of BP in these patients remains unknown. We recently experienced three PD patients diagnosed with BP. The skin injury was likely to be a trigger of BP in all the three PD patients. Nifedipine and icodextrin exposures were possible factors directly or indirectly affecting the onset of BP, because they were common in the three cases. We also report that the incidence of BP in PD patients was 3/478.3 person-years in a single-center 10-year study. This case series with a literature survey describes that the skin and tissue injuries are potential triggers responsible for the onset of BP in dialysis patients and that the incidence of BP in these patients seems to be much higher than that in the general population.
大疱性类天疱疮（BP）是一种自身免疫性表皮下疱病。尽管已有几例接受腹膜透析（PD）或血液透析的终末期肾病患者发生 BP 的报道，但这些患者的发病率仍不清楚。我们最近遇到了 3 例 PD 患者被诊断为 BP。在所有 3 例 PD 患者中，皮肤损伤可能是 BP 的诱因。硝苯地平及艾考糊精暴露可能是直接或间接影响 BP 发病的因素，因为这两种药物在这 3 例中都很常见。我们还报告称，在一项单中心 10 年研究中，PD 患者的 BP 发病率为 3/478.3 人年。本病例系列及文献综述描述了皮肤和组织损伤是导致透析患者发生 BP 的潜在诱因，且这些患者的 BP 发病率似乎远高于普通人群。
