Mashima Emi, Saito-Sasaki Natsuko, Sawada Yu
Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.
Diagnostics (Basel). 2024 Oct 12;14(20):2272. doi: 10.3390/diagnostics14202272.
: Bullous pemphigoid is an autoimmune bullous disease that frequently affects a large skin surface area, but it can also present in localized areas. It has been hypothesized that bullous pemphigoid affects the systemic functioning of different organs because inflammatory cells and cytokines circulate throughout numerous organs. : Recent clinical and experimental studies have revealed an association between bullous pemphigoid and systemic organ disorders. To avoid the emergence of systemic organ diseases, the significance of systemic treatment in cases of severe bullous pemphigoid should be emphasized. : Here, we discuss the specific molecular processes underlying typical systemic organ inflammatory diseases associated with bullous pemphigoids.
大疱性类天疱疮是一种自身免疫性大疱性疾病，常累及大面积皮肤，但也可局限于某些部位。据推测，大疱性类天疱疮会影响不同器官的全身功能，因为炎症细胞和细胞因子会在多个器官中循环。近期的临床和实验研究揭示了大疱性类天疱疮与全身器官疾病之间的关联。为避免全身器官疾病的出现，应强调在重症大疱性类天疱疮病例中进行全身治疗的重要性。在此，我们讨论与大疱性类天疱疮相关的典型全身器官炎症性疾病背后的具体分子过程。
