Department of Inorganic and Analytical Chemistry, Faculty of Science and Technology, University of Debrecen, Debrecen, Hungary.
Curr Med Chem. 2021;28(35):7209-7237. doi: 10.2174/0929867328666210405123952.
There has been a long tradition for a broad spectrum of applications of both natural and synthetic hydroxamic acids and derivatives. Even nowadays, a huge number of newly designed representatives (from different monohydroxamate-based compounds to siderophore conjugates) are used to develop potential drug candidates with desired activities. Since these compounds are effective metal-chelating agents, their biological roles and actions as well as their various applications, e.g., in the medicinal practice, are all in direct correlation with their metal complexation. Consequently, the knowledge of the stoichiometry and binding modes of metal complexes with hydroxamic acid-based ligands, their thermodynamic parameters, and speciation profiles in solution are crucial for scientists working in any of the above-mentioned fields. This review, in addition to presenting a few factors, which might affect the metal-binding capabilities of these organic ligands, displays and summarizes the different parameters typically used to give the stoichiometry, composition, and stability of the species formed in a solution equilibrium system in measurable concentration. Discussion of the possibilities for quantitative comparison of metal-binding effectivity and selectivity of various hydroxamic acids with each other by using solution equilibrium data is also the focus of this publication.
天然和合成羟肟酸及其衍生物在广泛的应用领域都有着悠久的传统。即使在今天，大量新设计的代表物（从不同的单羟肟酸基化合物到铁载体缀合物）也被用于开发具有所需活性的潜在药物候选物。由于这些化合物是有效的金属螯合剂，它们的生物作用和作用以及它们的各种应用，例如在医学实践中，都与它们的金属络合直接相关。因此，了解基于羟肟酸的配体与金属配合物的化学计量和键合模式、热力学参数以及溶液中的形态分布对于在上述任何领域工作的科学家都是至关重要的。除了介绍一些可能影响这些有机配体金属结合能力的因素外，本综述还展示和总结了通常用于确定在可测量浓度的溶液平衡体系中形成的物质的化学计量、组成和稳定性的不同参数。本文还讨论了通过使用溶液平衡数据定量比较各种羟肟酸的金属结合效力和选择性的可能性。
