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溴隐亭对性功能障碍影响的研究。

Study of the effects of bromocriptine on sexual impotence.

作者信息

Ambrosi B, Bara R, Travaglini P, Weber G, Beck Peccoz P, Rondena M, Elli R, Faglia G

出版信息

Clin Endocrinol (Oxf). 1977 Nov;7(5):417-21. doi: 10.1111/j.1365-2265.1977.tb03351.x.

Abstract

Serum testosterone, prolactin, LH, FSH and plasma 17 beta-oestradiol levels were determined in forty-seven male patients with sexual impotence. Low testosterone values and slightly elevated prolactin levels were observed in 19% and in 17% of cases, respectively. Since sexual function in the male seems to be controlled by both dopaminergic stimulatory and serotoninergic inhibitory mechanisms, bromocriptine was given orally to seventeen patients. As the preliminary results appeared encouraging, a double blind study was undertaken in the other thirty patients. No appreciable difference in hormonal pattern was noticed between bromocriptine and placebo treatment. As far as sexual function was concerned, good results were obtained in 52% of cases treated with bromocriptine and in 44% of patients given placebo.

摘要

对47例男性性功能障碍患者测定了血清睾酮、催乳素、促黄体生成素(LH)、促卵泡生成素(FSH)以及血浆17β -雌二醇水平。分别在19%和17%的病例中观察到睾酮值偏低和催乳素水平略有升高。由于男性性功能似乎受多巴胺能兴奋机制和5 -羟色胺能抑制机制两者控制,对17例患者口服了溴隐亭。鉴于初步结果令人鼓舞,对另外30例患者进行了双盲研究。溴隐亭治疗组和安慰剂治疗组之间在激素模式上未发现明显差异。就性功能而言,接受溴隐亭治疗的病例中有52%取得了良好效果,给予安慰剂的患者中有44%取得了良好效果。

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