Rosenberg P J, Livingstone D J, McLellan B A
Emergency Department, Sunnybrook Medical Centre, University of Toronto, Ontario, Canada.
Ann Emerg Med. 1988 Jul;17(7):681-3. doi: 10.1016/s0196-0644(88)80610-3.
Whole-bowel irrigation was studied in three volunteer subjects and compared with oral activated charcoal as a gastrointestinal decontamination procedure for acute drug overdose. The volunteer subjects were given 650 mg aspirin and were assigned randomly to the following treatment groups: 24-hour urine collection only; immediate whole-bowel irrigation with a polyethylene glycol solution; 50 g oral activated charcoal followed by whole-bowel irrigation; and oral activated charcoal alone. The cumulative 24-hour urinary salicylate excretion was measured in each trial. Catharsis was achieved rapidly with whole-bowel irrigation. Oral activated charcoal without catharsis was most effective in decreasing aspirin absorption (P = .011). These results do not support the routine use of a cathartic in combination with oral activated charcoal.
对三名志愿者进行了全肠道灌洗研究，并将其与口服活性炭作为急性药物过量的胃肠道净化程序进行比较。给志愿者服用650毫克阿司匹林，并随机分配到以下治疗组：仅收集24小时尿液；立即用聚乙二醇溶液进行全肠道灌洗；50克口服活性炭后进行全肠道灌洗；以及仅口服活性炭。在每项试验中测量累积24小时尿水杨酸排泄量。全肠道灌洗能迅速实现导泻。未进行导泻的口服活性炭在减少阿司匹林吸收方面最有效（P = 0.011）。这些结果不支持将泻药与口服活性炭联合常规使用。
