U.S. Army Brooke Army Medical Center, San Antonio, Texas;
U.S. Army Brooke Army Medical Center, San Antonio, Texas.
J Nucl Med Technol. 2021 Sep;49(3):246-249. doi: 10.2967/jnmt.120.261552. Epub 2021 Apr 5.
The goal of this work was to determine U.S. diagnostic reference levels (DRLs) and achievable administered activities (AAAs) for adult renal scintigraphy. Under an Institutional Review Board-approved protocol, data were collected from the Intersocietal Accreditation Commission during one 3-y accreditation cycle encompassing 110 facilities. Elements included radiopharmaceutical, administered activity, practice type, and examination volume. DRLs and AAAs were calculated and compared with non-U.S. values and societal recommendations as available. Ninety-three facilities provided data on Tc-mercaptoacetyltriglycine (Tc-MAG3), and 15 provided data on Tc-diethylenetriaminepentaacetic acid (Tc-DTPA) for adult renal scintigraphy exams. Analysis demonstrated a DRL of 392.2 MBq (10.6 mCi) for Tc-MAG3 and 531.7 MBq (14.4 mCi) for Tc-DTPA, with an AAA of 370 MBq (10 mCi) for Tc-MAG3 and 445.9 MBq (12.1 mCi) for Tc-DTPA. The resultant calculated novel U.S. DRLs and AAAs may serve as benchmarks that nuclear medicine facilities may use to refine renal scintigraphy protocols, reduce patient doses, and potentially guide future societal guideline recommendations.
这项工作的目的是确定美国成人肾闪烁显像的诊断参考水平（DRLs）和可实现的给予放射性活度（AAAs）。根据机构审查委员会批准的方案，数据是在一个涵盖 110 个设施的 3 年认证周期中，从协会间认证委员会收集的。元素包括放射性药物、给予放射性活度、实践类型和检查量。计算了 DRLs 和 AAAs，并与非美国值和可用的社会建议进行了比较。93 个设施提供了 Tc-巯基乙酰三甘氨酸（Tc-MAG3）的检查数据，15 个设施提供了 Tc-二乙三胺五乙酸（Tc-DTPA）的检查数据，用于成人肾闪烁显像检查。分析表明，Tc-MAG3 的 DRL 为 392.2 MBq（10.6 mCi），Tc-DTPA 的 DRL 为 531.7 MBq（14.4 mCi），Tc-MAG3 的 AAA 为 370 MBq（10 mCi），Tc-DTPA 的 AAA 为 445.9 MBq（12.1 mCi）。由此计算出的美国新的 DRLs 和 AAAs 可以作为核医学设施用来改进肾闪烁显像方案、降低患者剂量并可能指导未来社会指南建议的基准。
