Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, King's College London, London, UK.
Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Amyotroph Lateral Scler Frontotemporal Degener. 2021 Aug;22(5-6):336-340. doi: 10.1080/21678421.2020.1867181. Epub 2021 Apr 6.
Clinical stage in amyotrophic lateral sclerosis (ALS) can be assigned using King's staging with a simple protocol based on the number of CNS regions involved and the presence of significant nutritional or respiratory failure. It is important that the assigned clinical stage matches expectations, and generally corresponds with how a health care professional would intuitively stage the patient. We therefore investigated the relationship between King's clinical ALS stage and ALS stage as intuitively assigned by health care professionals. We wrote 17 case vignettes describing people with ALS at different disease stages from very early limited disease involvement through to severe, multi-domain disease. During two workshops, we asked health care professionals to intuitively stage the vignettes and compared the answers with the actual King's clinical ALS stage. There was a good correlation between King's clinical ALS stage and intuitively assigned stage, with a Spearman's Rank correlation coefficient of 0.64 ( < 0.001). There was no difference in the intuitive stages assigned by practitioners of different types or at different levels of experience. Across a spectrum of ALS scenarios, King's clinical ALS stage corresponds to intuitive ALS stage as assigned by a range of health care professionals.
肌萎缩侧索硬化症（ALS）的临床分期可采用基于 King 分期的简单方案进行，该方案基于受累中枢神经系统区域的数量和是否存在明显的营养或呼吸衰竭。重要的是，所分配的临床分期与预期相符，并且通常与医疗保健专业人员直观地对患者进行分期的方式相对应。因此，我们研究了 King 临床 ALS 分期与医疗保健专业人员直观分配的 ALS 分期之间的关系。我们编写了 17 个病例描述，描述了不同疾病阶段的 ALS 患者，从早期局限性疾病到严重的多领域疾病。在两次研讨会上，我们要求医疗保健专业人员直观地对病例进行分期，并将答案与实际的 King 临床 ALS 分期进行比较。King 临床 ALS 分期与直观分配的分期之间存在良好的相关性，Spearman 秩相关系数为 0.64（<0.001）。不同类型或经验水平的从业者分配的直观分期没有差异。在 ALS 各种情况下，King 临床 ALS 分期与一系列医疗保健专业人员直观分配的 ALS 分期相对应。
