缺血性脑能量代谢的长期恶化及与高血糖相关的酸中毒：通过连续31P核磁共振波谱研究人类脑梗死
Prolonged deterioration of ischemic brain energy metabolism and acidosis associated with hyperglycemia: human cerebral infarction studied by serial 31P NMR spectroscopy.
作者信息
Levine S R, Welch K M, Helpern J A, Chopp M, Bruce R, Selwa J, Smith M B
机构信息
Department of Neurology, Henry Ford Hospital, Detroit, MI 48202.
出版信息
Ann Neurol. 1988 Apr;23(4):416-8. doi: 10.1002/ana.410230423.
PMID:3382181
Abstract
We report on a patient with a large ischemic hemispherical stroke studied serially by 31P nuclear magnetic resonance spectroscopy. Persistent hyperglycemia was associated with prolonged acidosis in ischemic brain and failure of high-energy phosphate metabolism to recover. These in vivo human data support the concept that hyperglycemia adversely affects ischemic brain metabolism, pH, and clinical outcome.
摘要
我们报告了一名患有大面积缺血性半球卒中的患者，该患者通过31P核磁共振波谱进行了系列研究。持续性高血糖与缺血性脑内酸中毒延长以及高能磷酸代谢未能恢复有关。这些人体活体数据支持了高血糖对缺血性脑代谢、pH值和临床结果产生不利影响的观点。
Zotero 插件