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[肺癌手术治疗中肺功能保留与根治性兼顾——支气管成形术]

[Surgical treatment of lung cancer for both preserving lung function and maintaining radicality--bronchoplastic surgery].

作者信息

Nakagawa K, Seki M, Tsuchiya S, Matsubara T, Kinoshita I, Nishi M, Oh S, Tsuchiya E

机构信息

Dept. of Surgery, Cancer Institute Hospital, Tokyo.

出版信息

Gan To Kagaku Ryoho. 1988 Apr;15(4 Pt 2-2):1124-31.

PMID:3382187
Abstract

Fifty cases with lung cancer given bronchoplastic surgery were discussed. Five-year survival rates of all of the cases, those with squamous cell carcinoma, pathological stage I + II cases and absolute curative cases were 36%, 42%, 46% and 59%, respectively, excluding operation death and hospital death. These results were virtually comparable with those of all of the cases with lung cancer which were ever resected in our hospital. The prognosis for cases with adenocarcinoma and of cases operated with bronchoplasty was poor because of direct bronchial invasion from inter-lobar lymph-node metastasis. Hence, this procedure could be better indicated for cases with squamous cell carcinoma, direct primary tumor invasion of the bronchus, and these in which absolute curative operation could be expected clinically. As is characteristic, suture failure occurred in 3 cases, and 2 of them which were followed by pulmonary arterial fistula died of massive bleeding. Preoperative BAI (Bronchial Arterial Infusion had been performed in all 3 cases. It is suggested that there may will be some relation between BAI and suture failure. From the viewpoint of technique, both blood supply preserving and tension relaxing procedures are the most important to avoid suture failure.

摘要

对50例行支气管成形术的肺癌患者进行了讨论。排除手术死亡和医院死亡病例后,所有病例、鳞状细胞癌病例、病理分期为Ⅰ + Ⅱ期病例及绝对治愈病例的5年生存率分别为36%、42%、46%和59%。这些结果与我院以往所有接受切除的肺癌病例的结果基本相当。腺癌病例及接受支气管成形术的病例预后较差,原因是叶间淋巴结转移导致支气管直接受侵。因此,该手术更适合鳞状细胞癌、肿瘤直接侵犯支气管以及临床上有望进行绝对治愈性手术的病例。具有特征性的是,3例发生了缝合失败,其中2例随后出现肺动脉瘘并死于大出血。所有3例术前均进行了支气管动脉灌注(BAI)。提示BAI与缝合失败之间可能存在某种关联。从技术角度来看,保留血供和缓解张力的操作对于避免缝合失败最为重要。

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