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[根治性切除术后头颈部复发性癌症的重建]

[Radical excision followed by reconstruction of recurrent cancers of the head and neck].

作者信息

Inuyama Y, Fujii M, Tanaka J, Takaoka T, Hosoda H, Kawaura M, Toji M, Fujino T

机构信息

Dept. of Otolaryngology, School of Medicine, Keio University.

出版信息

Gan To Kagaku Ryoho. 1988 Apr;15(4 Pt 2-2):1306-12.

PMID:3382199
Abstract

Various modalities of treatment for recurrent cancers of the head and neck were studied and discussed, focusing especially on radical excision followed by reconstruction. Thirty-two patients with recurrent cancer of the head and neck were given this treatment over a 12-year period. Pectoralis major myocutaneous flap was most commonly used for reconstruction, while free latissimus dorsi myocutaneous flap with microneurovascular anastomosis was used for total cheek defect after surgery for cancer of the maxillary sinus. Five-year survival was 62% in cases of radical excision followed by reconstruction. Simple resection of recurrent lesions was conducted in 36 cases and the 5-year survival was also 62%. Radical neck dissection was performed in 22 cases in which cervical node metastases developed after control of the primary tumor, and the 5-year survival was 52%. On the other hand, the 5-year survival was not obtained in cases treated with radiotherapy alone in this series, while the 5-year survival was only 1% in cases treated with chemotherapy alone. It was concluded that surgery was the most reliable treatment for recurrent cancers of the head and neck, and that radical excision followed by reconstruction played an important role as salvage surgery.

摘要

对复发性头颈癌的各种治疗方式进行了研究和讨论,尤其着重于根治性切除后进行重建。在12年期间,32例复发性头颈癌患者接受了这种治疗。胸大肌肌皮瓣最常用于重建,而上颌窦癌手术后全颊部缺损则采用带显微神经血管吻合的背阔肌游离肌皮瓣。根治性切除后进行重建的病例5年生存率为62%。36例进行了复发病灶的单纯切除,5年生存率也为62%。22例在原发肿瘤得到控制后出现颈部淋巴结转移,进行了根治性颈清扫术,5年生存率为52%。另一方面,在本系列中,单纯放疗的病例未获得5年生存率,而单纯化疗的病例5年生存率仅为1%。得出的结论是,手术是复发性头颈癌最可靠的治疗方法,根治性切除后进行重建作为挽救性手术发挥了重要作用。

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