Department of Cardiology, Anqiu People's Hospital, Weifang, Shandong 262100, PR China.
Department of Cardiology, People's Hospital of Rizhao, Rizhao, Shandong 276800, PR China.
Per Med. 2021 May;18(3):213-221. doi: 10.2217/pme-2020-0136. Epub 2021 Apr 6.
This study discussed the clinical value and expression level of miR-455-5p in atherosclerosis (AS) patients. Meanwhile, its regulatory effect on the proliferation and migration of vascular smooth muscle cells (VSMCs) was further analyzed. Clinical experiments were detected by quantitative real-time PCR and receiver operating characteristic. Cell experiments were detected by CCK-8, transwell and luciferase reporter gene assay. miR-455-5p was low expressed in AS patients and had diagnostic value to distinguish AS patients from healthy controls. MiR-455-5p inhibited the proliferation and migration of VSMCs. was the target gene of miR-455-5p. MiR-455-5p may be used as a potential diagnostic biomarker for AS. MiR-455-5p may inhibit the proliferation and migration of VSMCs through targeting .
本研究探讨了 miR-455-5p 在动脉粥样硬化（AS）患者中的临床价值和表达水平，并进一步分析了其对血管平滑肌细胞（VSMCs）增殖和迁移的调控作用。临床实验通过实时定量 PCR 和受试者工作特征曲线进行检测，细胞实验通过 CCK-8、transwell 和荧光素酶报告基因检测进行检测。miR-455-5p 在 AS 患者中低表达，对区分 AS 患者和健康对照具有诊断价值。miR-455-5p 抑制 VSMCs 的增殖和迁移。是 miR-455-5p 的靶基因。miR-455-5p 可作为 AS 的潜在诊断生物标志物。miR-455-5p 可能通过靶向抑制 VSMCs 的增殖和迁移。
