Department of Family Medicine, Korea University College of Medicine, 73 Goryeodae-ro Seongbuk-gu, Seoul 02841, Korea.
Department of Statistics and Actuarial Science, Soongsil University, 369 Sangdo-Ro, Dongjak-Gu, Seoul 06978, Korea.
Eur J Prev Cardiol. 2022 Jan 11;28(16):1767-1773. doi: 10.1093/eurjpc/zwaa049.
Heart failure (HF) is associated with obesity, but the relationship between weight change and HF is inconsistent. We examined the relationship between weight change and the incidence of HF in the Korean population.
Retrospective cohort study design.
A total of 11 210 394 subjects (6 198 542 men and 5 011 852 women) >20 years of age were enrolled in this study. Weight change over 4 years divided into seven categories from weight loss ≥15% to weight gain ≥15%. The hazard ratios (HRs) and 95% confidence intervals for the incidence of HF were analysed. The HR of HF showed a slightly reverse J-shaped curve by increasing weight change in total and >15% weight loss shows the highest HR (HR 1.647) followed by -15 to -10% weight loss (HR = 1.444). When using normal body mass index with stable weight group as a reference, HR of HF decreased as weight increased in underweight subjects and weight gain ≥15% in obesity Stage II showed the highest HR (HR = 2.97). Sustained weight for 4 years in the underweight and obesity Stages I and II increased the incidence of HF (HR = 1.402, 1.092, and 1.566, respectively).
Both weight loss and weight gain increased HR for HF. Sustained weight in the obesity or underweight categories increased the incidence of HF.
心力衰竭（HF）与肥胖有关，但体重变化与 HF 的关系并不一致。我们研究了韩国人群中体重变化与 HF 发生率之间的关系。
回顾性队列研究设计。
共纳入 11210394 例年龄>20 岁的受试者（6198542 例男性和 5011852 例女性）。体重在 4 年内的变化分为从体重减轻≥15%到体重增加≥15%的七个类别。分析了 HF 发生率的风险比（HR）和 95%置信区间。HF 的 HR 随着体重变化的增加呈略微反向 J 形曲线，总体重减轻≥15%的 HR 最高（HR 1.647），其次是-15%至-10%的体重减轻（HR = 1.444）。当以正常体重指数和稳定体重组为参考时，体重不足的受试者体重增加和肥胖 II 期体重增加≥15%的 HR 降低（HR = 2.97）。体重不足和肥胖 I 和 II 期持续 4 年增加了 HF 的发生率（HR = 1.402、1.092 和 1.566）。
体重减轻和体重增加均增加了 HF 的 HR。肥胖或体重不足类别的体重持续增加会增加 HF 的发生率。
