Department of Neurosurgery, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, China.
J Int Med Res. 2021 Apr;49(4):3000605211002960. doi: 10.1177/03000605211002960.
To investigate the effect of supplemental dexmedetomidine in interventional embolism on cerebral oxygen metabolism in patients with intracranial aneurysms.
Ninety patients who underwent interventional embolism of intracranial aneurysms were equally divided into Group A and Group B. In Group A, dexmedetomidine was injected intravenously 10 minutes before inducing anesthesia, with a loading dose of 0.6 µg/kg followed by 0.4 µg/kg/hour. Group B received the same amount of normal saline by the same injection method. Heart rate (HR), mean arterial pressure (MAP), arterial-jugular venous oxygen difference [D(a-jv) (O)], cerebral oxygen extraction [CE (O)], and intraoperative propofol use were recorded before inducing anesthesia (T) and at five time points thereafter.
The amount of propofol in Group A was lower vs Group B. At all five time points after T, HR, MAP, D(a-jv) (O), and CE (O) in Group A were significantly lower vs Group B, with significant differences for jugular venous oxygen saturation (SO) and the oxygen content of the internal jugular vein (CO) between the groups.
Dexmedetomidine resulted in less intraoperative propofol, lower D(a-jv) (O) and CE (O), and improved cerebral oxygen metabolism.
研究介入栓塞术中辅助使用右美托咪定对颅内动脉瘤患者脑氧代谢的影响。
将 90 例行颅内动脉瘤介入栓塞术的患者等分为 A 组和 B 组。A 组在诱导麻醉前 10 分钟静脉注射右美托咪定，负荷剂量为 0.6μg/kg，然后以 0.4μg/kg/h 的速度输注。B 组以相同的注射方法给予相同剂量的生理盐水。记录麻醉诱导前（T）和此后五个时间点的心率（HR）、平均动脉压（MAP）、动静脉血氧差[D(a-jv)（O）]、脑氧摄取率[CE（O）]和术中丙泊酚的使用量。
A 组丙泊酚的用量低于 B 组。在 T 后五个时间点，A 组的 HR、MAP、D(a-jv)（O）和 CE（O）均明显低于 B 组，颈内静脉血氧饱和度（SO）和颈内静脉氧含量（CO）两组间存在显著差异。
右美托咪定可减少术中丙泊酚的用量，降低 D(a-jv)（O）和 CE（O），改善脑氧代谢。
