Cervantes H M, Munger L L, Ley D H, Ficken M D
Department of Food Animal and Equine Medicine, School of Veterinary Medicine, North Carolina State University, Raleigh 27606.
Avian Dis. 1988 Jan-Mar;32(1):140-2.
An infectious bursal disease (IBD)-vaccinated flock of 23,900 broilers, 17 days of age, experienced sudden onset of depression, dermatitis, and mortality. Postmortem examination showed extensive subcutaneous serosanguineous fluid accumulation over the pectoral muscles, discrete hepatic whitish foci, fluid-filled intestines, and small, flaccid bursae of Fabricius. Gram-stained impression smears from the affected areas revealed numerous gram-positive cocci. Aerobic culture of liver and subcutaneous tissue consistently produced heavy growth of penicillin-sensitive Staphyloccus aureus. Histopathologically, subcutaneous tissue showed diffuse hemorrhage and large numbers of gram-positive cocci with severe congestion and hemorrhage of the underlying skeletal muscle. Liver sections showed multiple, randomly scattered areas of acute coagulation necrosis with numerous gram-positive cocci. Bursal lesions were characterized by extensive follicular necrosis and collapse. A diagnosis of staphylococcal gangrenous dermatitis secondary to IBD was made. Mortality returned to preinfection levels within 72 hours after penicillin was added to the drinking water.
一群23900只17日龄接种过传染性法氏囊病（IBD）疫苗的肉鸡突然出现精神沉郁、皮炎和死亡。尸检显示胸肌上有广泛的皮下浆液性血性液体蓄积、肝脏散在白色病灶、肠管积液以及法氏囊小而松弛。对患病部位进行革兰氏染色压片检查发现大量革兰氏阳性球菌。肝脏和皮下组织的需氧培养始终产生大量对青霉素敏感的金黄色葡萄球菌。组织病理学检查显示，皮下组织有弥漫性出血，大量革兰氏阳性球菌，其下方骨骼肌严重充血和出血。肝脏切片显示多个随机散在的急性凝固性坏死区域，有大量革兰氏阳性球菌。法氏囊病变的特征是广泛的滤泡坏死和塌陷。诊断为IBD继发的葡萄球菌坏疽性皮炎。在饮用水中添加青霉素后72小时内死亡率恢复到感染前水平。
