突触结合蛋白 1：一种多功能蛋白，介导囊泡的对接、预备和融合。
Synaptotagmin-1: A Multi-Functional Protein that Mediates Vesicle Docking, Priming, and Fusion.
机构信息
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Department of Pharmacy, Southeast University, Dhaka, Bangladesh.
出版信息
Curr Protein Pept Sci. 2021;22(6):470-478. doi: 10.2174/1389203722666210325110231.
The fusion of secretory vesicles with the plasma membrane depends on the assembly of v-SNAREs (VAMP2/synaptobrevin2) and t-SNAREs (SNAP25/syntaxin1) into the SNARE complex. Vesicles go through several upstream steps, referred to as docking and priming, to gain fusion competence. The vesicular protein synaptotagmin-1 (Syt-1) is the principal Ca sensor for fusion in several central nervous system neurons and neuroendocrine cells and part of the docking complex for secretory granules. Syt-1 binds to the acceptor complex such as synaxin1, SNAP-25 on the plasma membrane to facilitate secretory vesicle docking, and upon Ca-influx, it promotes vesicle fusion. This review assesses the role of the Syt-1 protein involved in the secretory vesicle docking, priming, and fusion.
囊泡与质膜的融合取决于囊泡上的 v-SNARE（VAMP2/synaptobrevin2）和质膜上的 t-SNARE（SNAP25/syntaxin1）组装成 SNARE 复合体。囊泡经历了几个上游步骤，称为停靠和引发，以获得融合能力。囊泡蛋白突触结合蛋白 1（Syt-1）是几种中枢神经系统神经元和神经内分泌细胞中融合的主要 Ca 传感器，也是分泌颗粒的停靠复合物的一部分。Syt-1 与质膜上的接受体复合物（如 synaxin1、SNAP-25）结合，促进囊泡的停靠，在 Ca2+内流时，它促进囊泡融合。这篇综述评估了 Syt-1 蛋白在囊泡停靠、引发和融合中的作用。
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