The Vivian L. Smith Department of Neurosurgery, University of Texas Health Science Center, 6431 Fannin St. MSB 7.147, Houston, TX, 77030, USA.
Fluids Barriers CNS. 2021 Apr 6;18(1):17. doi: 10.1186/s12987-021-00250-7.
The vessels of the central nervous system (CNS) have unique barrier properties. The endothelial cells (ECs) which comprise the CNS vessels contribute to the barrier via strong tight junctions, specific transporters, and limited endocytosis which combine to protect the brain from toxins and maintains brain homeostasis. Blood-brain barrier (BBB) leakage is a serious secondary injury in various CNS disorders like stroke, brain tumors, and neurodegenerative disorders. Currently, there are no drugs or therapeutics available to treat specifically BBB damage after a brain injury. Growing knowledge in the field of epigenetics can enhance the understanding of gene level of the BBB and has great potential for the development of novel therapeutic strategies or targets to repair a disrupted BBB. In this brief review, we summarize the epigenetic mechanisms or regulators that have a protective or disruptive role for components of BBB, along with the promising approaches to regain the integrity of BBB.
中枢神经系统（CNS）的血管具有独特的屏障特性。构成 CNS 血管的内皮细胞（EC）通过紧密连接、特定转运体和有限的胞吞作用来维持屏障的完整性，这些共同作用保护大脑免受毒素侵害并维持大脑内环境稳定。血脑屏障（BBB）渗漏是中风、脑肿瘤和神经退行性疾病等各种 CNS 疾病的严重继发性损伤。目前，尚无药物或治疗方法可专门用于治疗脑损伤后的 BBB 损伤。在表观遗传学领域的不断发展可以提高对 BBB 基因水平的理解，并为开发修复受损 BBB 的新型治疗策略或靶点提供巨大潜力。在这篇简要综述中，我们总结了具有保护或破坏 BBB 组成部分作用的表观遗传机制或调节剂，以及恢复 BBB 完整性的有希望的方法。
