爱泼斯坦-巴尔病毒、人乳头瘤病毒和单纯疱疹病毒2共同存在会严重失调微小RNA的表达。
Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 co-presence severely dysregulates miRNA expression.
作者信息
Okoye Jude O, Ngokere Anthony A, Onyenekwe Charles C, Omotuyi Olaposi, Dada Deborah I
机构信息
Department of Medical Laboratory Science, School of Public and Allied Health, Babcock University, Ilishan-Remo, Ogun State, Nigeria.
Department of Medical Laboratory Science, Faculty of Health Sciences and Technology, College of Medicine, Nnamdi Azikiwe University, Nnewi campus, Anambra, Nigeria.
出版信息
Afr J Lab Med. 2021 Mar 16;10(1):975. doi: 10.4102/ajlm.v10i1.975. eCollection 2021.
This cross-sectional study evaluated the expression of miR-let-7b, miR-21, miR-125b, miR-143, miR-145, miR-155, miR-182, miR-200c, p53 gene, Ki67, SCCA1 and CD4+ T-cell counts among 319 women, to Epstein-Barr virus, human papillomavirus and herpes simplex virus 2 mono-infections and co-infections, using enzyme-linked immunosorbent assay and reverse transcriptase-polymerase chain reaction methods. This study suggests that malignancies associated with viral co-infection could be diagnosed early by monitoring cluster of differentiation 4+ T-cell counts and serum expression of miR-145 and miR-182.
这项横断面研究使用酶联免疫吸附测定法和逆转录聚合酶链反应方法，评估了319名女性中miR-let-7b、miR-21、miR-125b、miR-143、miR-145、miR-155、miR-182、miR-200c、p53基因、Ki67、鳞状细胞癌抗原1（SCCA1）和CD4 + T细胞计数，以检测爱泼斯坦-巴尔病毒、人乳头瘤病毒和单纯疱疹病毒2型的单一感染及合并感染情况。该研究表明，通过监测分化簇4 + T细胞计数以及miR-145和miR-182的血清表达，可早期诊断与病毒合并感染相关的恶性肿瘤。
Zotero 插件