Gazi University, Faculty of Dentistry, Oral Pathology Department, Ankara, Turkey.
Med Oral Patol Oral Cir Bucal. 2011 Mar 1;16(2):e170-4. doi: 10.4317/medoral.16.e170.
The aim of the present study was to assess the prevalence of Herpes Simplex virus, Epstein Barr virus and Human Papilloma virus -16 in oral lichen planus cases and to evaluate whether any clinical variant, histopathological or demographic feature correlates with these viruses.
The study was conducted on 65 cases. Viruses were detected immunohistochemically. We evaluated the histopathological and demographic features and statistically analysed correlation of these features with Herpes Simplex virus, Epstein Barr virus and Human Papilloma virus-16 positivity.
Herpes Simplex virus was positive in six (9%) cases and this was not statistically significant. The number of Epstein Barr virus positive cases was 23 (35%) and it was statistically significant. Human Papilloma virus positivity in 14 cases (21%) was statistically significant. Except basal cell degeneration in Herpes Simplex virus positive cases, we did not observe any significant correlation between virus positivity and demographic or histopathological features. However an increased risk of Epstein Barr virus and Human Papilloma virus infection was noted in oral lichen planus cases.
Taking into account the oncogenic potential of both viruses, oral lichen planus cases should be detected for the presence of these viruses.
本研究旨在评估口腔扁平苔藓病例中单纯疱疹病毒、爱泼斯坦-巴尔病毒和人乳头瘤病毒-16 的流行情况，并评估任何临床变异、组织病理学或人口统计学特征是否与这些病毒相关。
本研究共纳入 65 例病例。通过免疫组织化学方法检测病毒。我们评估了组织病理学和人口统计学特征，并对这些特征与单纯疱疹病毒、爱泼斯坦-巴尔病毒和人乳头瘤病毒-16 阳性之间的相关性进行了统计学分析。
单纯疱疹病毒阳性的病例有 6 例（9%），但无统计学意义。爱泼斯坦-巴尔病毒阳性的病例有 23 例（35%），有统计学意义。人乳头瘤病毒阳性的病例有 14 例（21%），有统计学意义。除单纯疱疹病毒阳性病例的基底细胞变性外，我们未观察到病毒阳性与人口统计学或组织病理学特征之间存在任何显著相关性。然而，口腔扁平苔藓病例中观察到爱泼斯坦-巴尔病毒和人乳头瘤病毒感染的风险增加。
鉴于这两种病毒的致癌潜力，应检测口腔扁平苔藓病例中这些病毒的存在。
